Intersectin: Difference between revisions

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<StructureSection load='1fos' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='6gbu' size='340' side='right' caption='Caption for this structure' scene=''>
article describing Jmol <ref>PMID:21638687</ref> to the rescue.


== Function ==
== Function ==
'''Intersectin''' (ITSN) is an endocytic multidomain scaffold protein in neurons and is important regulator of synaptic vescicles replenishment at hippocampal synapses.  The replenishment is needed in order to sustain neurotransmission during periods of elevated activity. ITSN interacts with synapsin I through its SH3 domains<ref>PMID:29229830</ref>. 


== Disease ==
== Disease ==


== Relevance ==
== Relevance ==
ITSN 2 might be a potential biomarker for discrimination of severe acute pancreatitis to improve the prognosis of patients<ref>PMID:31880027</ref>. Overexpression of ITSN 1 is implicated for human neurodegenerative diseases such as Down's syndrome and Alzheimer's disease<ref>PMID:21876463</ref>.


== Structural highlights ==
== Structural highlights ==
Line 15: Line 18:


==3D structures of intersectin==
==3D structures of intersectin==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


*Intersectin 1
*Intersectin 1
**[[3fia]] - hITSN1 EH domain 1-111<br />
**[[2khn]] - hITSN1 EH domain - NMR<br />
**[[2kgr]] - hITSN1 residues 210-312 - NMR<br />
**[[6h5t]] - hITSN1 1st SH3 domain 741-835<br />
**[[4iim]] - hITSN1 2nd SH3 domain + peptide<br />
**[[6gbu]] - hITSN1 4th SH3 domain 1055-1133 + FCHSD2<br />
**[[1ki1]] - hITSN1 DBL+PH domains 1229-1580 + Cdc42<br />
**[[3qbv]] - hITSN1 DBL+PH domains (mutant) + Cdc42<br />
**[[3jv3]] - mITSN1 5th SH3+DH domains 1151-1431 <br />


*Intersectin 2
*Intersectin 2
Line 22: Line 38:
**[[1uff]] - hITSN2 1st SH3 domain 761-841 - NMR<br />
**[[1uff]] - hITSN2 1st SH3 domain 761-841 - NMR<br />
**[[1j3t]] - hITSN2 2nd SH3 domain 897-957 - NMR<br />
**[[1j3t]] - hITSN2 2nd SH3 domain 897-957 - NMR<br />
**[[4iio]] - hITSN2 2nd SH3 domain + peptide<br />
**[[1uhf]] - hITSN2 3rd SH3 domain 982-1037 - NMR<br />
**[[1uhf]] - hITSN2 3rd SH3 domain 982-1037 - NMR<br />
**[[1ue9]] - hITSN2 4th SH3 domain 1055-1121 - NMR<br />
**[[1ue9]] - hITSN2 4th SH3 domain 1055-1121 - NMR<br />
Line 31: Line 48:
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]

Revision as of 11:01, 29 April 2020


Function

Intersectin (ITSN) is an endocytic multidomain scaffold protein in neurons and is important regulator of synaptic vescicles replenishment at hippocampal synapses. The replenishment is needed in order to sustain neurotransmission during periods of elevated activity. ITSN interacts with synapsin I through its SH3 domains[1].

Disease

Relevance

ITSN 2 might be a potential biomarker for discrimination of severe acute pancreatitis to improve the prognosis of patients[2]. Overexpression of ITSN 1 is implicated for human neurodegenerative diseases such as Down's syndrome and Alzheimer's disease[3].

Structural highlights

Caption for this structure

Drag the structure with the mouse to rotate

3D structures of intersectin3D structures of intersectin

Updated on 29-April-2020 {{#tree:id=OrganizedByTopic|openlevels=0|

  • Intersectin 1
    • 3fia - hITSN1 EH domain 1-111
    • 2khn - hITSN1 EH domain - NMR
    • 2kgr - hITSN1 residues 210-312 - NMR
    • 6h5t - hITSN1 1st SH3 domain 741-835
    • 4iim - hITSN1 2nd SH3 domain + peptide
    • 6gbu - hITSN1 4th SH3 domain 1055-1133 + FCHSD2
    • 1ki1 - hITSN1 DBL+PH domains 1229-1580 + Cdc42
    • 3qbv - hITSN1 DBL+PH domains (mutant) + Cdc42
    • 3jv3 - mITSN1 5th SH3+DH domains 1151-1431
  • Intersectin 2
    • 1uff - hITSN2 1st SH3 domain 761-841 - NMR
    • 1j3t - hITSN2 2nd SH3 domain 897-957 - NMR
    • 4iio - hITSN2 2nd SH3 domain + peptide
    • 1uhf - hITSN2 3rd SH3 domain 982-1037 - NMR
    • 1ue9 - hITSN2 4th SH3 domain 1055-1121 - NMR
    • 1udl - hITSN2 5th SH3 domain 1102-1186 - NMR
    • 3gf9 - hITSN2 RhoGEF domain 1102-1378
    • 3jzy - hITSN2 C2 domain 1173-1664


ReferencesReferences

  1. ↑ . Correction for Gerth et al., Intersectin associates with synapsin and regulates its nanoscale localization and function. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E11060. doi:, 10.1073/pnas.1720226115. Epub 2017 Dec 11. PMID:29229830 doi:http://dx.doi.org/10.1073/pnas.1720226115
  2. ↑ Li J, Bu X, Chen X, Xiong P, Chen Z, Yu L. Predictive value of long non-coding RNA intersectin 1-2 for occurrence and in-hospital mortality of severe acute pancreatitis. J Clin Lab Anal. 2019 Dec 27:e23170. doi: 10.1002/jcla.23170. PMID:31880027 doi:http://dx.doi.org/10.1002/jcla.23170
  3. ↑ Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O'Bryan JP. Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 2011 Oct 26;22(15):767-72. doi: 10.1097/WNR.0b013e32834ae348. PMID:21876463 doi:http://dx.doi.org/10.1097/WNR.0b013e32834ae348

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Michal Harel, Alexander Berchansky
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