1b36: Difference between revisions

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{{STRUCTURE_1b36|  PDB=1b36  |  SCENE=  }}  
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'''SOLUTION STRUCTURE OF THE HAIRPIN RIBOZYME LOOP B DOMAIN RNA, NMR, 10 STRUCTURES'''
===SOLUTION STRUCTURE OF THE HAIRPIN RIBOZYME LOOP B DOMAIN RNA, NMR, 10 STRUCTURES===




==Overview==
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The hairpin ribozyme is a small catalytic RNA with a unique two-domain structure. Here we present the solution structure of the loop B domain of the hairpin ribozyme, which contains most of the catalytically essential nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal loop that forms one of the largest non-Watson-Crick segments of base pairing thus far determined by either NMR or crystallography. Since the solution structure of the smaller loop A domain has been previously solved, an NMR structure-based model of the 22,000 Mr hairpin ribozyme-substrate open complex emerges by joining the two domain structures. Strikingly, catalytically essential functional groups for the loop B domain are concentrated within an expanded minor groove, presenting a clear docking surface for the loop A domain.
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==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B36 OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B36 OCA].  


==Reference==
==Reference==
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[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
[[Category: Tetraloop receptor]]
[[Category: Tetraloop receptor]]
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Revision as of 18:07, 30 June 2008

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SOLUTION STRUCTURE OF THE HAIRPIN RIBOZYME LOOP B DOMAIN RNA, NMR, 10 STRUCTURESSOLUTION STRUCTURE OF THE HAIRPIN RIBOZYME LOOP B DOMAIN RNA, NMR, 10 STRUCTURES

Template:ABSTRACT PUBMED 10074938

About this StructureAbout this Structure

Full experimental information is available from OCA.

ReferenceReference

Solution structure of the loop B domain from the hairpin ribozyme., Butcher SE, Allain FH, Feigon J, Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:10074938

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