1b0i: Difference between revisions

Revision as of 17:59, 30 June 2008

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File:1b0i.png

Template:STRUCTURE 1b0i

ALPHA-AMYLASE FROM ALTEROMONAS HALOPLANCTISALPHA-AMYLASE FROM ALTEROMONAS HALOPLANCTIS

Template:ABSTRACT PUBMED 9862804

About this StructureAbout this Structure

1B0I is a Single protein structure of sequence from Pseudoalteromonas haloplanktis. Full crystallographic information is available from OCA.

ReferenceReference

Structures of the psychrophilic Alteromonas haloplanctis alpha-amylase give insights into cold adaptation at a molecular level., Aghajari N, Feller G, Gerday C, Haser R, Structure. 1998 Dec 15;6(12):1503-16. PMID:9862804

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''ALPHA-AMYLASE FROM ALTEROMONAS HALOPLANCTIS'''
+===ALPHA-AMYLASE FROM ALTEROMONAS HALOPLANCTIS===
-==Overview==
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-Background:. Enzymes from psychrophilic (cold-adapted) microorganisms operate at temperatures close to 0 degreesC, where the activity of their mesophilic and thermophilic counterparts is drastically reduced. It has generally been assumed that thermophily is associated with rigid proteins, whereas psychrophilic enzymes have a tendency to be more flexible. Results:. Insights into the cold adaptation of proteins are gained on the basis of a psychrophilic protein's molecular structure. To this end, we have determined the structure of the recombinant form of a psychrophilic alpha-amylase from Alteromonas haloplanctis at 2.4 A resolution. We have compared this with the structure of the wild-type enzyme, recently solved at 2.0 A resolution, and with available structures of their mesophilic counterparts. These comparative studies have enabled us to identify possible determinants of cold adaptation. Conclusions:. We propose that an increased resilience of the molecular surface and a less rigid protein core, with less interdomain interactions, are determining factors of the conformational flexibility that allows efficient enzyme catalysis in cold environments.
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 [[Category: Beta-alpha-eight barrel]]
 [[Category: Psychrophilic enzyme]]
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