2gnk: Difference between revisions

<table><tr><td colspan='2'>[[2gnk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GNK FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gnk OCA], [http://pdbe.org/2gnk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gnk RCSB], [http://www.ebi.ac.uk/pdbsum/2gnk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gnk ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/GLNK_ECOLI GLNK_ECOLI]] P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity).