6y2g: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6y2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y2g OCA], [http://pdbe.org/6y2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y2g RCSB], [http://www.ebi.ac.uk/pdbsum/6y2g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y2g ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6y2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y2g OCA], [http://pdbe.org/6y2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y2g RCSB], [http://www.ebi.ac.uk/pdbsum/6y2g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y2g ProSAT]</span></td></tr> | ||
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== Publication Abstract from PubMed == | |||
The COVID-19 pandemic caused by SARS-CoV-2 is a global health emergency. An attractive drug target among coronaviruses is the main protease (M(pro), 3CL(pro)), due to its essential role in processing the polyproteins that are translated from the viral RNA. We report the X-ray structures of the unliganded SARS-CoV-2 M(pro) and its complex with an alpha-ketoamide inhibitor. This was derived from a previously designed inhibitor but with the P3-P2 amide bond incorporated into a pyridone ring to enhance the half-life of the compound in plasma. Based on the structure, we developed the lead compound into a potent inhibitor of the SARS-CoV-2 M(pro) The pharmacokinetic characterization of the optimized inhibitor reveals a pronounced lung tropism and suitability for administration by the inhalative route. | |||
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors.,Zhang L, Lin D, Sun X, Curth U, Drosten C, Sauerhering L, Becker S, Rox K, Hilgenfeld R Science. 2020 Mar 20. pii: science.abb3405. doi: 10.1126/science.abb3405. PMID:32198291<ref>PMID:32198291</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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<div class="pdbe-citations 6y2g" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||