Undecaprenyl pyrophosphate synthase: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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== Function == | == Function == | ||
'''Undecaprenyl pyrophosphate synthase''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors. | '''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transferase''' or '''poly-cys-prenyltransferase''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors. | ||
== Relevance == | == Relevance == | ||
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**[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br /> | **[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br /> | ||
**[[5xk3]] – StUPP – ''Streptmyces''<br /> | **[[5xk3]] – StUPP – ''Streptmyces''<br /> | ||
**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br /> | |||
*Undecaprenyl pyrophosphate synthase complexes | *Undecaprenyl pyrophosphate synthase complexes | ||
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**[[1x09]] – EcUPP (mutant) + Mg + IPP<br /> | **[[1x09]] – EcUPP (mutant) + Mg + IPP<br /> | ||
**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br /> | **[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br /> | ||
**[[5cqj]] – EcUPP + inhibitor <br /> | **[[5cqj]], [[5zhe]] – EcUPP + inhibitor <br /> | ||
**[[5kh4]] – SpUPP + FPP <br /> | **[[5kh4]] – SpUPP + FPP <br /> | ||
**[[5kh5]] – SpUPP + inhibitor <br /> | **[[5kh5]] – SpUPP + inhibitor <br /> | ||
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**[[5xk7]] – StUPP + DMAPP <br /> | **[[5xk7]] – StUPP + DMAPP <br /> | ||
**[[5xk9]] – StUPP + GSPP + DMAPP <br /> | **[[5xk9]] – StUPP + GSPP + DMAPP <br /> | ||
**[[6szg]], [[6szh]] - | **[[6szg]], [[6szh]] - AbUPP + inhibitor<br /> | ||
}} | }} | ||