5ap7: Difference between revisions
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<StructureSection load='5ap7' size='340' side='right'caption='[[5ap7]], [[Resolution|resolution]] 2.45Å' scene=''> | <StructureSection load='5ap7' size='340' side='right'caption='[[5ap7]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ap7]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5ap7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AP7 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SVE:N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>SVE</scene | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SVE:N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>SVE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ap7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ap7 OCA], [https://pdbe.org/5ap7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ap7 RCSB], [https://www.ebi.ac.uk/pdbsum/5ap7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ap7 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Blagg | [[Category: Blagg J]] | ||
[[Category: Boxall | [[Category: Boxall K]] | ||
[[Category: Burke | [[Category: Burke R]] | ||
[[Category: Cheung | [[Category: Cheung KM]] | ||
[[Category: Faisal | [[Category: Faisal A]] | ||
[[Category: Gurden | [[Category: Gurden MD]] | ||
[[Category: Hoelder | [[Category: Hoelder S]] | ||
[[Category: Linardopoulos | [[Category: Linardopoulos S]] | ||
[[Category: Mak | [[Category: Mak G]] | ||
[[Category: McAndrew | [[Category: McAndrew C]] | ||
[[Category: Naud S]] | |||
[[Category: Naud | [[Category: Schmitt J]] | ||
[[Category: Schmitt | [[Category: Westwood IM]] | ||
[[Category: Westwood | [[Category: Wood A]] | ||
[[Category: Wood | [[Category: Workman P]] | ||
[[Category: Workman | [[Category: Van Montfort R]] | ||
[[Category: | |||