3bwp: Difference between revisions
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<StructureSection load='3bwp' size='340' side='right'caption='[[3bwp]], [[Resolution|resolution]] 3.10Å' scene=''> | <StructureSection load='3bwp' size='340' side='right'caption='[[3bwp]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3bwp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BWP OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[3bwp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BWP FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bwp OCA], [https://pdbe.org/3bwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bwp RCSB], [https://www.ebi.ac.uk/pdbsum/3bwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bwp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
Revision as of 11:27, 19 January 2022
Crystal structure of a self-spliced group II intronCrystal structure of a self-spliced group II intron
Structural highlights
Publication Abstract from PubMedGroup II introns are self-splicing ribozymes that catalyze their own excision from precursor transcripts and insertion into new genetic locations. Here we report the crystal structure of an intact, self-spliced group II intron from Oceanobacillus iheyensis at 3.1 angstrom resolution. An extensive network of tertiary interactions facilitates the ordered packing of intron subdomains around a ribozyme core that includes catalytic domain V. The bulge of domain V adopts an unusual helical structure that is located adjacent to a major groove triple helix (catalytic triplex). The bulge and catalytic triplex jointly coordinate two divalent metal ions in a configuration that is consistent with a two-metal ion mechanism for catalysis. Structural and functional analogies support the hypothesis that group II introns and the spliceosome share a common ancestor. Crystal structure of a self-spliced group II intron.,Toor N, Keating KS, Taylor SD, Pyle AM Science. 2008 Apr 4;320(5872):77-82. PMID:18388288[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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