2efl: Difference between revisions

<table><tr><td colspan='2'>[[2efl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EFL FirstGlance]. <br>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2efl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2efl OCA], [http://pdbe.org/2efl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2efl RCSB], [http://www.ebi.ac.uk/pdbsum/2efl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2efl ProSAT], [http://www.topsan.org/Proteins/RSGI/2efl TOPSAN]</span></td></tr>

[[http://www.uniprot.org/uniprot/FNBP1_HUMAN FNBP1_HUMAN]] Note=A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.  

[[http://www.uniprot.org/uniprot/FNBP1_HUMAN FNBP1_HUMAN]] May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.<ref>PMID:15252009</ref> <ref>PMID:16326391</ref> <ref>PMID:16318909</ref> <ref>PMID:16418535</ref> <ref>PMID:17512409</ref>