1hgb: Difference between revisions
New page: left|200px<br /> <applet load="1hgb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hgb, resolution 2.1Å" /> '''HIGH RESOLUTION CRYS... |
No edit summary |
||
| Line 6: | Line 6: | ||
==Overview== | ==Overview== | ||
The origin of co-operativity in haemoglobin (Hb) resides in the reduced, affinity of the T-state. T-state Hb crystals grown from polyethyleneglycol, can be liganded without the molecule switching to the R high affinity, state. X-ray analysis of T-state alpha-oxy Hb and T-state met Hb has, identified the structural basis for reduced affinity. The nature of the, chemical tension at the haem environment is different in the alpha and, beta haems. There are small but definite structural changes associated, with ligation in the T-state: these prove to be mostly in the same, direction as the larger changes that occur in the T-->R transition. | The origin of co-operativity in haemoglobin (Hb) resides in the reduced, affinity of the T-state. T-state Hb crystals grown from polyethyleneglycol, can be liganded without the molecule switching to the R high affinity, state. X-ray analysis of T-state alpha-oxy Hb and T-state met Hb has, identified the structural basis for reduced affinity. The nature of the, chemical tension at the haem environment is different in the alpha and, beta haems. There are small but definite structural changes associated, with ligation in the T-state: these prove to be mostly in the same, direction as the larger changes that occur in the T-->R transition. | ||
==Disease== | |||
Known diseases associated with this structure: Erythremias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Erythremias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Erythrocytosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], HPFH, deletion type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Heinz body anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Heinz body anemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Heinz body anemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Hemoglobin H disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Hypochromic microcytic anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Methemoglobinemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Methemoglobinemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Sickle cell anemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Thalassemia, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141850 141850]], Thalassemia-beta, dominant inclusion-body OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]], Thalassemias, alpha- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141800 141800]], Thalassemias, beta- OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900 141900]] | |||
==About this Structure== | ==About this Structure== | ||
| Line 22: | Line 25: | ||
[[Category: oxygen transport]] | [[Category: oxygen transport]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:17:43 2007'' | ||
