6lzg: Difference between revisions
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==Structure of novel coronavirus spike receptor-binding domain complexed with its receptor ACE2== | |||
<StructureSection load='6lzg' size='340' side='right'caption='[[6lzg]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6lzg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LZG FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Angiotensin-converting_enzyme_2 Angiotensin-converting enzyme 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.23 3.4.17.23] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzg OCA], [http://pdbe.org/6lzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lzg RCSB], [http://www.ebi.ac.uk/pdbsum/6lzg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzg ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN]] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Angiotensin-converting enzyme 2]] | |||
[[Category: Large Structures]] | |||
[[Category: Qi, J X]] | |||
[[Category: Song, H]] | |||
[[Category: Wang, Q H]] | |||
[[Category: Novel coronavirus]] | |||
[[Category: Receptor]] | |||
[[Category: Spike protein]] | |||
[[Category: Viral protein]] | |||