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| {{STRUCTURE_1alx| PDB=1alx | SCENE= }} | | {{STRUCTURE_1alx| PDB=1alx | SCENE= }} |
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| '''GRAMICIDIN D FROM BACILLUS BREVIS (METHANOL SOLVATE)'''
| | ===GRAMICIDIN D FROM BACILLUS BREVIS (METHANOL SOLVATE)=== |
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| ==Overview==
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| The linear pentadecapeptide antibiotic gramicidin D is a heterogeneous mixture of six components. Precise refinements of three-dimensional structures of naturally occurring gramicidin D in crystals obtained from methanol, ethanol, and n-propanol demonstrate the unexpected presence of stable left-handed antiparallel double-helical heterodimers that vary with the crystallization solvent. The side chains of Trp residues in the three structures exhibit sequence-specific patterns of conformational preference. Tyr substitution for Trp at position 11 appears to favor beta ribbon formation and stabilization of the antiparallel double helix that acts as a template for gramicidin folding and nucleation of different crystal forms. The fact that a minor component in a heterogeneous mixture influences aggregation and crystal nucleation has potential applications to other systems in which anomalous behavior is exhibited by aggregation of apparently homogeneous materials, such as the enigmatic behavior of prion proteins. | | The line below this paragraph, {{ABSTRACT_PUBMED_9788907}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9788907 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9788907}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Smith, G D.]] | | [[Category: Smith, G D.]] |
| [[Category: Peptide antibiotic]] | | [[Category: Peptide antibiotic]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:25:58 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:07:25 2008'' |