2boc: Difference between revisions
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<StructureSection load='2boc' size='340' side='right'caption='[[2boc]], [[Resolution|resolution]] 3.01Å' scene=''> | <StructureSection load='2boc' size='340' side='right'caption='[[2boc]], [[Resolution|resolution]] 3.01Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2boc]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2boc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOC FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=T1A:TETRAETHYLARSONIUM+ION'>T1A</scene>, <scene name='pdbligand=TL:THALLIUM+(I)+ION'>TL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=T1A:TETRAETHYLARSONIUM+ION'>T1A</scene>, <scene name='pdbligand=TL:THALLIUM+(I)+ION'>TL</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bl8|1bl8]], [[1f6g|1f6g]], [[1j95|1j95]], [[1jq1|1jq1]], [[1jq2|1jq2]], [[1jvm|1jvm]], [[1k4c|1k4c]], [[1k4d|1k4d]], [[1r3i|1r3i]], [[1r3j|1r3j]], [[1r3k|1r3k]], [[1r3l|1r3l]], [[1s5h|1s5h]], [[2bob|2bob]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bl8|1bl8]], [[1f6g|1f6g]], [[1j95|1j95]], [[1jq1|1jq1]], [[1jq2|1jq2]], [[1jvm|1jvm]], [[1k4c|1k4c]], [[1k4d|1k4d]], [[1r3i|1r3i]], [[1r3j|1r3j]], [[1r3k|1r3k]], [[1r3l|1r3l]], [[1s5h|1s5h]], [[2bob|2bob]]</div></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2boc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2boc OCA], [https://pdbe.org/2boc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2boc RCSB], [https://www.ebi.ac.uk/pdbsum/2boc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2boc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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*[[Antibody 3D structures|Antibody 3D structures]] | *[[Antibody 3D structures|Antibody 3D structures]] | ||
*[[Potassium channel 3D structures|Potassium channel 3D structures]] | *[[Potassium channel 3D structures|Potassium channel 3D structures]] | ||
*[[3D structures of non-human antibody|3D structures of non-human antibody]] | |||
== References == | == References == | ||
<references/> | <references/> |