6kh5: Difference between revisions
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<StructureSection load='6kh5' size='340' side='right'caption='[[6kh5]], [[Resolution|resolution]] 2.29Å' scene=''> | <StructureSection load='6kh5' size='340' side='right'caption='[[6kh5]], [[Resolution|resolution]] 2.29Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6kh5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KH5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[6kh5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Kuruma_prawn Kuruma prawn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KH5 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Ferroxidase]] | [[Category: Ferroxidase]] | ||
[[Category: Kuruma prawn]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen, H]] | [[Category: Chen, H]] | ||
Revision as of 10:09, 4 March 2020
Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodesDesign and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes
Structural highlights
Function[T2B7E1_PENJP] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.[RuleBase:RU361145] Publication Abstract from PubMedMetal-organic frameworks (MOFs) hold great promise for numerous applications. However, proteins, carriers of biological functions in living systems, have not yet been fully explored as building blocks for the construction of MOFs. Here, we presented a strategy for the fabrication of binary MOFs. Considering octahedral ferritin symmetry, we firstly incorporated four His 2 (His-His) motifs into the exterior surface of ferritin nanocage nearby each C 4 channel, yielding protein linkers with multiple metal binding sites (bisH-SF). Secondly, by adding nickel ions to bisH-SF solutions to triggers the self-assembly of ferritin nanocages into a porous 3D crystalline MOF with designed protein lattice, where two adjacent ferritin molecules along the C 4 symmetry axes are bridged by four dinuclear or tetranuclear nickel clusters depending on Ni 2+ concentration. This work provides a simple approach for precise control over a binary protein-metal crystalline framework, and resulting MOFs exhibited inherent ferroxidase activity and peroxidase-like catalytic activity. Structural Insight into Binary Protein MOFs with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes.,Gu C, Chen H, Wang Y, Zhang T, Wang H, Zhao G Chemistry. 2019 Dec 9. doi: 10.1002/chem.201905315. PMID:31820500[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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