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==Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLK-G12== | |||
<StructureSection load='6uft' size='340' side='right'caption='[[6uft]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6uft]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UFT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uft OCA], [http://pdbe.org/6uft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uft RCSB], [http://www.ebi.ac.uk/pdbsum/6uft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uft ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bontoxilysin]] | |||
[[Category: Large Structures]] | |||
[[Category: Jin, R]] | |||
[[Category: Lam, K]] | |||
[[Category: Antitoxin]] | |||
[[Category: Receptor-binding domain]] | |||
[[Category: Toxin]] | |||
[[Category: Toxin-antitoxin complex]] | |||
[[Category: Vhh]] | |||
Revision as of 09:55, 4 March 2020
Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLK-G12Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLK-G12
Structural highlights
Function[BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. |
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