1xc5: Difference between revisions
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<StructureSection load='1xc5' size='340' side='right'caption='[[1xc5]], [[NMR_Ensembles_of_Models | 28 NMR models]]' scene=''> | <StructureSection load='1xc5' size='340' side='right'caption='[[1xc5]], [[NMR_Ensembles_of_Models | 28 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1xc5]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1xc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XC5 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xc5 OCA], [https://pdbe.org/1xc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xc5 RCSB], [https://www.ebi.ac.uk/pdbsum/1xc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xc5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] |