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| [[Image:1adq.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1adq| PDB=1adq | SCENE= }} | | {{STRUCTURE_1adq| PDB=1adq | SCENE= }} |
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| '''CRYSTAL STRUCTURE OF A HUMAN IGM RHEUMATOID FACTOR FAB IN COMPLEX WITH ITS AUTOANTIGEN IGG FC'''
| | ===CRYSTAL STRUCTURE OF A HUMAN IGM RHEUMATOID FACTOR FAB IN COMPLEX WITH ITS AUTOANTIGEN IGG FC=== |
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| ==Overview==
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| Rheumatoid factors are the characteristic autoantibodies of rheumatoid arthritis, which bind to the Fc regions of IgG molecules. Here we report the crystal structure of the Fab fragment of a patient-derived IgM rheumatoid factor (RF-AN) complexed with human IgG4 Fc, at 3.2 A resolution. This is the first structure of an autoantibody-autoantigen complex. The epitope recognised in IgG Fc includes the C gamma 2/C gamma 3 cleft region, and overlaps the binding sites of bacterial Fc-binding proteins. The antibody residues involved in autorecognition are all located at the edge of the conventional combining site surface, leaving much of the latter available, potentially, for recognition of a different antigen. Since an important contact residue is somatic mutation, the structure implicates antigen-driven selection, following somatic mutation of germline genes, in the production of pathogenic rheumatoid factors.
| | The line below this paragraph, {{ABSTRACT_PUBMED_9145108}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9145108 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9145108}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Taussig, M J.]] | | [[Category: Taussig, M J.]] |
| [[Category: Rheumatoid factor auto-antibody complex]] | | [[Category: Rheumatoid factor auto-antibody complex]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:08:08 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:38:07 2008'' |