Sequestosome: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 20: | Line 20: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
Domains: PB1 1-102; ZZ 120-180; UBA 387-436 | |||
[[1q02]], [[2jy7]], [[2jy8]], [[2k0b]], [[2knv]] – hSQS UBA domain – human - NMR<br /> | [[1q02]], [[2jy7]], [[2jy8]], [[2k0b]], [[2knv]] – hSQS UBA domain – human - NMR<br /> | ||
[[6jm4]] – hSQS-1 PB1 domain (mutant)<br /> | [[6jm4]] – hSQS-1 PB1 domain (mutant)<br /> | ||
[[6miu]] – hSQS-1 ZZ domain <br /> | [[4uf8]], [[4uf9]], [[6tgy]], [[6th3]] – hSQS-1 PB1 domain – Cryo EM<br /> | ||
[[5yp7]], [[5yp8]], [[5ypa]], [[5ypb]], [[5ypc]], [[5ype]], [[5ypg]], [[5yph]], [[5ypi]], [[6miu]] – hSQS-1 ZZ domain<br /> | |||
[[6mj7]] – hSQS-1 ZZ domain + Arg<br /> | [[6mj7]] – hSQS-1 ZZ domain + Arg<br /> | ||
[[6khz]] – hSQS-1 ZZ domain + Gly<br /> | |||
[[2ktr]] – rSQS PB1 domain – rat - NMR<br /> | [[2ktr]] – rSQS PB1 domain – rat - NMR<br /> | ||
[[2kkc]] – rSQS PB1 domain (mutant) - NMR<br /> | [[2kkc]] – rSQS PB1 domain (mutant) - NMR<br /> | ||
[[4mjs]] – hSQS-1 PB1 domain + protein kinase C zeta type<br /> | [[4mjs]] – hSQS-1 PB1 domain + protein kinase C zeta type<br /> | ||
[[ | [[3b0f]] – mSQS UBA domain – mouse <br /> | ||
[[ | [[2rru]] – mSQS UBA domain - NMR<br /> | ||
Revision as of 12:36, 1 November 2020
FunctionSequestosome (SQS) or p62, is required for the formation and autophagic degredation of polyubiquitin-containg bodies. SQS may regulate signaling cascades through ubiquitination[1]. Structural highlightsSQS is a multi-domain protein. SQS domain structure includes:
RelevanceSQS is associated with fibrillary tangles in Alzheimer disease[2]. 3D structures of sequestosomeUpdated on 18-May-2025 Domains: PB1 1-102; ZZ 120-180; UBA 387-436 1q02, 2jy7, 2jy8, 2k0b, 2knv – hSQS UBA domain – human - NMR 6jm4 – hSQS-1 PB1 domain (mutant)
|
| ||||||||||
ReferencesReferences
- ↑ Seibenhener ML, Babu JR, Geetha T, Wong HC, Krishna NR, Wooten MW. Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol. 2004 Sep;24(18):8055-68. PMID:15340068 doi:10.1128/MCB.24.18.8055-8068.2004
- ↑ Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Prog Neurobiol. 2012 Jan;96(1):87-95. doi: 10.1016/j.pneurobio.2011.11.005. Epub , 2011 Nov 22. PMID:22138392 doi:http://dx.doi.org/10.1016/j.pneurobio.2011.11.005