Sentrin-specific protease

Sentrin-specific protease 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins. Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide. (PDB entry 2iy0).

spinqualitylabelsall models Structure of human Senp1 catalytic domain (grey) complex with SUMO1 (green) and RanGAP C terminal (pink) (PDB entry 2iy0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of sentrin-specific protease3D structures of sentrin-specific protease

Updated on 15-November-2023

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• Sentrin-specific protease 1
  • 2ckg, 2iyc – hSenp1 catalytic domain – human
    
  • 2xph, 2xre – hSenp1 catalytic domain + Co
    
  • 2iy1, 2g4d – hSenp1 catalytic domain (mutant) + SUMO1
    
  • 2ckh, 2iyd – hSenp1 catalytic domain + SUMO2
    
  • 6nnq – hSenp1 catalytic domain + SUMO3
    
  • 2iy0 – hSenp1 catalytic domain + SUMO1 + RanGAP C terminal
    
• Sentrin-specific protease 2
  • 1th0 – hSenp2 catalytic domain
    
  • 1tgz – hSenp2 catalytic domain + SUMO1
    
  • 2io0, 5aek – hSenp2 catalytic domain (mutant) + SUMO1 precursor
    
  • 3zo5 - hSenp2 catalytic domain (mutant) + SUMO2 precursor
    
  • 2io1 – hSenp2 catalytic domain (mutant) + SUMO3 precursor
    
  • 2io3 – hSenp2 catalytic domain (mutant) + SUMO2 + RanGAP C terminal
    
  • 2io2 – hSenp2 catalytic domain (mutant) + SUMO1 + RanGAP C terminal
    
• Sentrin-specific protease 7
  • 3eay – hSenp7 catalytic domain + SUMO1
    
  • 7r2e – hSenp7 catalytic domain + SUMO2
    
• Sentrin-specific protease 8
  • 1xt9, 2bkr – hSenp8 + Nedd8
    
  • 2bkq – hSenp8