GTPase HRas: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 30: | Line 30: | ||
== Structural highlights == | == Structural highlights == | ||
Interactions with the <scene name='37/379455/Cv/6'>nucleotide phosphate moiety in the active site</scene> of GTPase Hras determine its active conformation<ref>PMID:242356730</ref>. Water molecules shown as red spheres. | Interactions with the <scene name='37/379455/Cv/6'>nucleotide phosphate moiety in the active site</scene> of GTPase Hras determine its active conformation<ref>PMID:242356730</ref>. Water molecules shown as red spheres. | ||
==3D structures of GTPase Hras== | |||
[[GTPase Hras 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
| Line 47: | Line 49: | ||
*HRAS p21 catalytic domain complex with nucleotides | *HRAS p21 catalytic domain complex with nucleotides | ||
**[[1q21]], [[4q21]] – hHRAS + GDP<BR / > | |||
**[[1crp]], [[1crq]], [[1crr]], [[1aa9]] – hHRAS + GDP - NMR<BR / > | **[[1crp]], [[1crq]], [[1crr]], [[1aa9]] – hHRAS + GDP - NMR<BR / > | ||
**[[ | **[[4l9s]], [[6dzh]], [[6mqt]], [[1lf0]], [[1zw6]], [[2cl6]], [[2cl7]], [[2clc]], [[2evw]], [[1jah]], [[1jai]] - hHRAS (mutant) + GDP<br /> | ||
**[[5vbe]], [[5vbz]] - hHRAS (mutant) + GDP + pyrazole derivative<br /> | **[[5vbe]], [[5vbz]] - hHRAS (mutant) + GDP + pyrazole derivative<br /> | ||
**[[5zc6]] - hHRAS (mutant) + GNP + naphthalene derivative<br /> | |||
**[[5wdo]] - hHRAS + GMPPNP<br /> | **[[5wdo]] - hHRAS + GMPPNP<br /> | ||
**[[4l9w]], [[5wdp]], [[5wdq]] - hHRAS (mutant) + GMPPNP<br /> | **[[4l9w]], [[5wdp]], [[5wdq]] - hHRAS (mutant) + GMPPNP<br /> | ||
**[[6q21]], [[121p]] – hHRAS + GCP<BR / > | **[[6q21]], [[121p]] – hHRAS + GCP<BR / > | ||
**[[1qra]] - hHRAS + GTP<BR / > | **[[1qra]] - hHRAS + GTP<BR / > | ||
**[[1lf0]], [[1zw6]], [[2cl6]], [[2cl7]], [[2clc]], [[2evw]], [[1jah]], [[1jai]]- hHRAS (mutant) + GTP<BR / > | |||
**[[1clu]], [[1rvd]], [[1iaq]], [[1gnr]] - hHRAS (mutant) + GTP derivative<br / > | |||
**[[1ctq]], [[4efl]], [[4rsg]], [[5b2z]], [[5b30]], [[5x9s]] - hHRAS + GPPNHP<BR / > | **[[1ctq]], [[4efl]], [[4rsg]], [[5b2z]], [[5b30]], [[5x9s]] - hHRAS + GPPNHP<BR / > | ||
**[[1xcm]], [[2cl0]], [[2rga]], [[2rgb]], [[2rgc]], [[2rgd]], [[2rge]], [[2rgg]], [[3kkm]], [[3kkn]], [[4efm]], [[4efn]] - hHRAS (mutant) + GPPNHP<BR / > | **[[1xcm]], [[2cl0]], [[2rga]], [[2rgb]], [[2rgc]], [[2rgd]], [[2rge]], [[2rgg]], [[3kkm]], [[3kkn]], [[4efm]], [[4efn]] - hHRAS (mutant) + GPPNHP<BR / > | ||
**[[1gnp]], [[1gnq]] - hHRAS + guanylate derivative<br / > | **[[1gnp]], [[1gnq]], [[6q21]] - hHRAS + guanylate derivative<br / > | ||
**[[4xvq]], [[4xvr]] - hHRAS (mutant) + guanylate derivative<br /> | **[[4xvq]], [[4xvr]] - hHRAS (mutant) + guanylate derivative<br /> | ||
**[[2lcf]] - hHRAS (mutant) + guanylate derivative - NMR<BR / > | **[[2lcf]] - hHRAS (mutant) + guanylate derivative - NMR<BR / > | ||
| Line 64: | Line 69: | ||
**[[3lbh]], [[3lbi]], [[3lbn]] - hHRAS + salt + guanylate derivative<br / > | **[[3lbh]], [[3lbi]], [[3lbn]] - hHRAS + salt + guanylate derivative<br / > | ||
**[[3l8y]] - hHRAS + cyclen + guanylate derivative<br / > | **[[3l8y]] - hHRAS + cyclen + guanylate derivative<br / > | ||
**[[ | **[[2lwi]] – hHRAS (mutant) + inhibitor + GNP<br /> | ||
*HRAS p21 catalytic domain complex with protein | *HRAS p21 catalytic domain complex with protein | ||
| Line 75: | Line 78: | ||
**[[1nvu]], [[1nvv]], [[1nvx]], [[1xd2]], [[4nyi]], [[4nyj]], [[4nym]] - hHRAS (mutant) + son of sevenless-1 homolog<BR / > | **[[1nvu]], [[1nvv]], [[1nvx]], [[1xd2]], [[4nyi]], [[4nyj]], [[4nym]] - hHRAS (mutant) + son of sevenless-1 homolog<BR / > | ||
**[[4uru]], [[4urv]], [[4urw]], [[4urx]], [[4ury]], [[4urz]], [[4us0]], [[4us1]], [[4us2]] - hHRAS + son of sevenless-1 + inhibitor<br /> | **[[4uru]], [[4urv]], [[4urw]], [[4urx]], [[4ury]], [[4urz]], [[4us0]], [[4us1]], [[4us2]] - hHRAS + son of sevenless-1 + inhibitor<br /> | ||
**[[6bvj]], [[6bvk]] - hHRAS + son of sevenless-1 + activator<br /> | |||
**[[6bvi]], [[6bvl]], [[6bvm]], [[6cuo]], [[6cup]], [[6cur]], [[6d55]], [[6d56]], [[6d59]], [[6d5e]], [[6d5g]], [[6d5h]], [[6d5j]], [[6d5l]], [[6d5m]], [[6d5v]], [[6d5w]] - hHRAS (mutant) + son of sevenless-1 + activator<br /> | |||
**[[1k8r]] - hHRAS + Byr2 RAS-binding domain<BR / > | **[[1k8r]] - hHRAS + Byr2 RAS-binding domain<BR / > | ||
**[[2c5l]] - hHRAS (mutant) + phosphoinositide-specific phospholipase RA2 domain<BR / > | **[[2c5l]] - hHRAS (mutant) + phosphoinositide-specific phospholipase RA2 domain<BR / > | ||
**[[2uzi]], [[2vh5]] - hHRAS (mutant) + antibody<BR / > | **[[2uzi]], [[2vh5]] - hHRAS (mutant) + antibody<BR / > | ||
**[[3ddc]] - hHRAS (mutant) + Ras association domain containing family protein RAS-binding domain<BR / > | **[[3ddc]] - hHRAS (mutant) + Ras association domain containing family protein RAS-binding domain<BR / > | ||
**[[3kud]] | **[[3kud]] - hHRAS + RAF proto-oncogene Ser/Thr-protein kinase + GDP<br /> | ||
**[[4g0n]] - hHRAS + RAF proto-oncogene Ser/Thr-protein kinase + GNP<br /> | |||
**[[6ntc]], [[4g3x]], [[6ntd]] - hHRAS (mutant) + RAF proto-oncogene Ser/Thr-protein kinase + GNP<br /> | |||
**[[1lfd]] - hHRAS + Ral guanine nucleotide dissociation stimulator RAS-binding domain<br /> | **[[1lfd]] - hHRAS + Ral guanine nucleotide dissociation stimulator RAS-binding domain<br /> | ||
**[[4k81]] – hHRAS + growth factor receptor-bound protein<br /> | **[[4k81]] – hHRAS + growth factor receptor-bound protein<br /> | ||
| Line 87: | Line 94: | ||
**[[6amb]] – hHRAS + afadin<br /> | **[[6amb]] – hHRAS + afadin<br /> | ||
**[[1he8]] – hHRAS (mutant) + P3K<br /> | **[[1he8]] – hHRAS (mutant) + P3K<br /> | ||
**[[6kyh]] – hHRAS + Shank3 + GNP<br /> | |||
**[[ | |||
}} | }} | ||