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			Thyroxine (T4) is the main precursor of T3 hormone (triiodothyronine). They both control physiological processes like urinary water absorption and also cell metabolism. T4 is produced by the thyroid gland. Its concentration is used to diagnose thyroid diseases <ref name= "t4">Eshar, D., Nau, M. R., & Pohlman, L. M. (2017). PLASMA THYROXINE (T4) CONCENTRATION IN ZOO-KEPT BLACK-TAILED PRAIRIE DOGS (CYNOMYS LUDOVICIANUS). Journal of Zoo and Wildlife Medicine, 48(1), 116–120. doi:10.1638/2016-0073.1 </ref>.
	Two hormone binding sites are located at the dimer–dimer region bind T4 with negative cooperativity. Under physiological conditions, the bound between the natural ligand and the tetramer can’t be broken down. Moreover, there is only one hormone bound per tetramer. The negative cooperativity mechanism		Two hormone binding sites are located at the dimer–dimer region bind T4 with negative cooperativity. Under physiological conditions, the bound between the natural ligand and the tetramer can’t be broken down. Moreover, there is only one hormone bound per tetramer. The negative cooperativity mechanism