How B-lactam drugs work: Difference between revisions

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	How do bacteria become resistant to penicillin and other beta lactam antibiotics? Some bacteria have an enzyme called penicillinase, which inactivates penicillin by cutting the beta lactam ring to form a carboxylic acid and an amine. This prevents the antibiotic from reacting with the serine residue in the transpeptidase, making it inactive. The gene for this enzyme is located on a bacterial plasmid, and can be transferred from one bacteria to another, causing antibacterial resistance to spread.		How do bacteria become resistant to penicillin and other beta lactam antibiotics? Some bacteria have an enzyme called penicillinase, which inactivates penicillin by cutting the beta lactam ring to form a carboxylic acid and an amine. This prevents the antibiotic from reacting with the serine residue in the transpeptidase, making it inactive. The gene for this enzyme is located on a bacterial plasmid, and can be transferred from one bacteria to another, causing antibacterial resistance to spread.

	For more information about penicillin binding proteins, please see the Molecule of the Month page for penicillin binding proteins. [https://pdb101.rcsb.org/motm/29]		For more information about penicillin binding proteins, please see the Molecule of the Month page for penicillin binding proteins. [https://pdb101.rcsb.org/motm/29] and [[Penicillin-binding protein]].