1a8q: Difference between revisions

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{{STRUCTURE_1a8q|  PDB=1a8q  |  SCENE=  }}  
{{STRUCTURE_1a8q|  PDB=1a8q  |  SCENE=  }}  


'''BROMOPEROXIDASE A1'''
===BROMOPEROXIDASE A1===




==Overview==
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The structures of cofactor-free haloperoxidases from Streptomyces aureofaciens, Streptomyces lividans, and Pseudomonas fluorescens have been determined at resolutions between 1.9 A and 1.5 A. The structures of two enzymes complexed with benzoate or propionate identify the binding site for the organic acids which are required for the haloperoxidase activity. Based on these complexes and on the structure of an inactive variant, a reaction mechanism is proposed for the halogenation reaction with peroxoacid and hypohalous acid as reaction intermediates. Comparison of the structures suggests that a specific halide binding site is absent in the enzymes but that hydrophobic organic compounds may fit into the active site pocket for halogenation at preferential sites.
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{{ABSTRACT_PUBMED_9642069}}


==About this Structure==
==About this Structure==
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[[Category: Haloperoxidase]]
[[Category: Haloperoxidase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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Revision as of 16:23, 30 June 2008

File:1a8q.png

Template:STRUCTURE 1a8q

BROMOPEROXIDASE A1BROMOPEROXIDASE A1

Template:ABSTRACT PUBMED 9642069

About this StructureAbout this Structure

1A8Q is a Single protein structure of sequence from Streptomyces aureofaciens. Full crystallographic information is available from OCA.

ReferenceReference

Structural investigation of the cofactor-free chloroperoxidases., Hofmann B, Tolzer S, Pelletier I, Altenbuchner J, van Pee KH, Hecht HJ, J Mol Biol. 1998 Jun 19;279(4):889-900. PMID:9642069

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