6edx: Difference between revisions

<table><tr><td colspan='2'>[[6edx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EDX FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.009&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6edx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6edx OCA], [https://pdbe.org/6edx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6edx RCSB], [https://www.ebi.ac.uk/pdbsum/6edx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6edx ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SGK3_HUMAN SGK3_HUMAN] Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.<ref>PMID:12054501</ref> <ref>PMID:12397388</ref> <ref>PMID:12590200</ref> <ref>PMID:12632189</ref> <ref>PMID:12634932</ref> <ref>PMID:12650886</ref> <ref>PMID:12911626</ref> <ref>PMID:14706641</ref> <ref>PMID:15040001</ref> <ref>PMID:15044175</ref> <ref>PMID:15319523</ref> <ref>PMID:15496163</ref> <ref>PMID:15737648</ref> <ref>PMID:15845389</ref> <ref>PMID:16036218</ref> <ref>PMID:16888620</ref> <ref>PMID:17167223</ref> <ref>PMID:18005662</ref> <ref>PMID:19293151</ref> <ref>PMID:20511718</ref> <ref>PMID:21865597</ref>  

[[Category: Homo sapiens]]

[[Category: Chandra M]]

[[Category: Collins BM]]