6bu6: Difference between revisions

<table><tr><td colspan='2'>[[6bu6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BU6 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=E8V:4,4-(2-aminopyridine-3,5-diyl)bis(2,6-difluorophenol)'>E8V</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bu6 OCA], [https://pdbe.org/6bu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bu6 RCSB], [https://www.ebi.ac.uk/pdbsum/6bu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bu6 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>  

[[Category: Homo sapiens]]

[[Category: Arruda P]]

[[Category: Azevedo A]]

[[Category: Counago RM]]

[[Category: Edwards AM]]

[[Category: Elkins JM]]

[[Category: Ferreira M]]

[[Category: Gama F]]

[[Category: Guimaraes C]]

[[Category: Mascarello A]]

[[Category: Massirer KB]]

[[Category: Santiago AS]]

[[Category: De Souza GP]]

[[Category: Dos Reis CV]]