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| <StructureSection load='5v6e' size='340' side='right'caption='[[5v6e]], [[Resolution|resolution]] 3.51Å' scene=''> | | <StructureSection load='5v6e' size='340' side='right'caption='[[5v6e]], [[Resolution|resolution]] 3.51Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[5v6e]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V6E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V6E FirstGlance]. <br> | | <table><tr><td colspan='2'>[[5v6e]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V6E FirstGlance]. <br> |
| </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5v6b|5v6b]], [[5v6h|5v6h]], [[5v6r|5v6r]], [[5v6t|5v6t]]</td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.506Å</td></tr> |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gipc1, Gipc, Rgs19ip1, Semcap1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Myo6, Sv ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v6e OCA], [https://pdbe.org/5v6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v6e RCSB], [https://www.ebi.ac.uk/pdbsum/5v6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v6e ProSAT]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v6e OCA], [http://pdbe.org/5v6e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v6e RCSB], [http://www.ebi.ac.uk/pdbsum/5v6e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v6e ProSAT]</span></td></tr> | |
| </table> | | </table> |
| == Disease ==
| |
| [[http://www.uniprot.org/uniprot/MYO6_MOUSE MYO6_MOUSE]] Note=Defects in Myo6 are the cause of Snell's waltzer, a condition characterized by circling, head-tossing, deafness and hyperactivity.
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| == Function == | | == Function == |
| [[http://www.uniprot.org/uniprot/GIPC1_MOUSE GIPC1_MOUSE]] Inhibits endothelial cell migration (in vitro). May be involved in G protein-linked signaling (By similarity). [[http://www.uniprot.org/uniprot/MYO6_MOUSE MYO6_MOUSE]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells. | | [https://www.uniprot.org/uniprot/GIPC1_MOUSE GIPC1_MOUSE] Inhibits endothelial cell migration (in vitro). May be involved in G protein-linked signaling (By similarity). |
| <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| </StructureSection> | | </StructureSection> |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Lk3 transgenic mice]] | | [[Category: Mus musculus]] |
| [[Category: Shang, G]] | | [[Category: Shang G]] |
| [[Category: Zhang, X]] | | [[Category: Zhang X]] |
| [[Category: Helical bundle]]
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| [[Category: Protein binding]]
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