5d9h: Difference between revisions

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<StructureSection load='5d9h' size='340' side='right'caption='[[5d9h]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='5d9h' size='340' side='right'caption='[[5d9h]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5d9h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D9H FirstGlance]. <br>
<table><tr><td colspan='2'>[[5d9h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D9H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Stk39, Spak ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d9h OCA], [https://pdbe.org/5d9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d9h RCSB], [https://www.ebi.ac.uk/pdbsum/5d9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d9h ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d9h OCA], [http://pdbe.org/5d9h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d9h RCSB], [http://www.ebi.ac.uk/pdbsum/5d9h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d9h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/STK39_MOUSE STK39_MOUSE]] May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation (PubMed:21317537, PubMed:23542070).<ref>PMID:21317537</ref> <ref>PMID:23542070</ref>
[https://www.uniprot.org/uniprot/STK39_MOUSE STK39_MOUSE] May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation (PubMed:21317537, PubMed:23542070).<ref>PMID:21317537</ref> <ref>PMID:23542070</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Cobb MH]]
[[Category: Cobb, M H]]
[[Category: Goldsmith EJ]]
[[Category: Goldsmith, E J]]
[[Category: Juang YC]]
[[Category: Juang, Y C]]
[[Category: Taylor CA]]
[[Category: Taylor, C A]]
[[Category: Hypertension]]
[[Category: Kinase]]
[[Category: Ste20]]
[[Category: Stk39]]
[[Category: Transferase]]

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