6pof: Difference between revisions

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'''Unreleased structure'''


The entry 6pof is ON HOLD until Paper Publication
==Structure of human ATP citrate lyase==
 
<StructureSection load='6pof' size='340' side='right'caption='[[6pof]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6pof]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6POF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6POF FirstGlance]. <br>
Description:  
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ATP_citrate_synthase ATP citrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.8 2.3.3.8] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pof OCA], [http://pdbe.org/6pof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pof RCSB], [http://www.ebi.ac.uk/pdbsum/6pof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pof ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN]] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: ATP citrate synthase]]
[[Category: Large Structures]]
[[Category: Ronen, M]]
[[Category: Xuepeng, W]]
[[Category: Apo]]
[[Category: Lyase]]

Revision as of 11:20, 1 January 2020

Structure of human ATP citrate lyaseStructure of human ATP citrate lyase

Structural highlights

6pof is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:ATP citrate synthase, with EC number 2.3.3.8
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ACLY_HUMAN] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.[1]

References

  1. ↑ Lin R, Tao R, Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013 Aug 22;51(4):506-18. doi: 10.1016/j.molcel.2013.07.002. Epub 2013 , Aug 8. PMID:23932781 doi:http://dx.doi.org/10.1016/j.molcel.2013.07.002

6pof, resolution 4.30Å

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