1a3k: Difference between revisions

Revision as of 15:56, 30 June 2008

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File:1a3k.png

Template:STRUCTURE 1a3k

X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTIONX-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION

Template:ABSTRACT PUBMED 9582341

About this StructureAbout this Structure

1A3K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution., Seetharaman J, Kanigsberg A, Slaaby R, Leffler H, Barondes SH, Rini JM, J Biol Chem. 1998 May 22;273(21):13047-52. PMID:9582341

Page seeded by OCA on Mon Jun 30 15:56:06 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION'''
+===X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION===
-==Overview==
+<!--
-Galectins are a family of lectins which share similar carbohydrate recognition domains (CRDs) and affinity for small beta-galactosides, but which show significant differences in binding specificity for more complex glycoconjugates. We report here the x-ray crystal structure of the human galectin-3 CRD, in complex with lactose and N-acetyllactosamine, at 2.1-A resolution. This structure represents the first example of a CRD determined from a galectin which does not show the canonical 2-fold symmetric dimer organization. Comparison with the published structures of galectins-1 and -2 provides an explanation for the differences in carbohydrate-binding specificity shown by galectin-3, and for the fact that it fails to form dimers by analogous CRD-CRD interactions.
+The line below this paragraph, {{ABSTRACT_PUBMED_9582341}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9582341 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_9582341}}
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 [[Category: Ige-binding protein]]
 [[Category: Lectin]]
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