5c31: Difference between revisions

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 <StructureSection load='5c31' size='340' side='right'caption='[[5c31]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5c31]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C31 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C31 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5c31]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C31 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c31 OCA], [https://pdbe.org/5c31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c31 RCSB], [https://www.ebi.ac.uk/pdbsum/5c31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c31 ProSAT]</span></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pkz|3pkz]], [[2r0q|2r0q]], [[5c32|5c32]], [[5c34|5c34]], [[5c35|5c35]]</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c31 OCA], [http://pdbe.org/5c31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c31 RCSB], [http://www.ebi.ac.uk/pdbsum/5c31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c31 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/BIN3_STAAU BIN3_STAAU]] Potential DNA invertase.
+[https://www.uniprot.org/uniprot/BIN3_STAAU BIN3_STAAU] Potential DNA invertase.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Members of the serine family of site-specific recombinases exchange DNA strands via 180 degrees rotation about a central protein-protein interface. Modeling of this process has been hampered by the lack of structures in more than one rotational state for any individual serine recombinase. Here we report crystal structures of the catalytic domains of four constitutively active mutants of the serine recombinase Sin, providing snapshots of rotational states not previously visualized for Sin, including two seen in the same crystal. Normal mode analysis predicted that each tetramer's lowest frequency mode (i.e. most accessible large-scale motion) mimics rotation: two protomers rotate as a pair with respect to the other two. Our analyses also suggest that rotation is not a rigid body movement around a single symmetry axis but instead uses multiple pivot points and entails internal motions within each subunit.
+Snapshots of a molecular swivel in action.,Trejo CS, Rock RS, Stark WM, Boocock MR, Rice PA Nucleic Acids Res. 2018 Jun 1;46(10):5286-5296. doi: 10.1093/nar/gkx1309. PMID:29315406<ref>PMID:29315406</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 5c31" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Rice, P A]]
+[[Category: Staphylococcus aureus]]
-[[Category: Trejo, C S]]
+[[Category: Rice PA]]
-[[Category: Conformational flexibility]]
+[[Category: Trejo CS]]
-[[Category: Dna binding protein]]
-[[Category: Serine recombinase]]
-[[Category: Site specific recombinase]]