6tky: Difference between revisions

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'''Unreleased structure'''


The entry 6tky is ON HOLD
==Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42==
 
<StructureSection load='6tky' size='340' side='right'caption='[[6tky]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
Authors: Barford, D., Fan, D., Cronin, N., Yang, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6tky]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TKY FirstGlance]. <br>
Description: Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Small_monomeric_GTPase Small monomeric GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.2 3.6.5.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tky OCA], [http://pdbe.org/6tky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tky RCSB], [http://www.ebi.ac.uk/pdbsum/6tky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tky ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DOC10_HUMAN DOC10_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.[UniProtKB:Q8BZN6] [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Small monomeric GTPase]]
[[Category: Barford, D]]
[[Category: Barford, D]]
[[Category: Cronin, N]]
[[Category: Fan, D]]
[[Category: Yang, J]]
[[Category: Yang, J]]
[[Category: Fan, D]]
[[Category: Dock10 gef cdc42 gtpase]]
[[Category: Cronin, N]]
[[Category: Signaling protein]]

Revision as of 19:21, 22 January 2020

Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42

Structural highlights

6tky is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:Small monomeric GTPase, with EC number 3.6.5.2
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DOC10_HUMAN] Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.[UniProtKB:Q8BZN6] [CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.[1] [2] [3]

References

  1. ↑ Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell. 2004 May;15(5):2205-17. Epub 2004 Feb 20. PMID:14978216 doi:10.1091/mbc.E03-07-0493
  2. ↑ Oceguera-Yanez F, Kimura K, Yasuda S, Higashida C, Kitamura T, Hiraoka Y, Haraguchi T, Narumiya S. Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. J Cell Biol. 2005 Jan 17;168(2):221-32. Epub 2005 Jan 10. PMID:15642749 doi:10.1083/jcb.200408085
  3. ↑ Modzelewska K, Newman LP, Desai R, Keely PJ. Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. J Biol Chem. 2006 Dec 8;281(49):37527-35. Epub 2006 Oct 12. PMID:17038317 doi:10.1074/jbc.M604342200

6tky, resolution 2.55Å

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