6soy: Difference between revisions

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<StructureSection load='6soy' size='340' side='right'caption='[[6soy]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='6soy' size='340' side='right'caption='[[6soy]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6soy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SOY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SOY FirstGlance]. <br>
<table><tr><td colspan='2'>[[6soy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SOY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">13J3.10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei]), 13J3.09 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei]), TF, PRO1400 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6soy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6soy OCA], [http://pdbe.org/6soy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6soy RCSB], [http://www.ebi.ac.uk/pdbsum/6soy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6soy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6soy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6soy OCA], [https://pdbe.org/6soy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6soy RCSB], [https://www.ebi.ac.uk/pdbsum/6soy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6soy ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.  
[https://www.uniprot.org/uniprot/ESAG6_TRYBB ESAG6_TRYBB] Transferrin receptor subunit involved in receptor-mediated acquisition of iron from the environment by binding host TF/transferrin.<ref>PMID:18680745</ref> <ref>PMID:31636418</ref> <ref>PMID:7957316</ref> <ref>PMID:8522581</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
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<div class="pdbe-citations 6soy" style="background-color:#fffaf0;"></div>
==See Also==
*[[Transferrin 3D structures|Transferrin 3D structures]]
*[[Transferrin receptor|Transferrin receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Carrington, M]]
[[Category: Trypanosoma brucei]]
[[Category: Higgins, M K]]
[[Category: Carrington M]]
[[Category: Trevor, C]]
[[Category: Higgins MK]]
[[Category: Protein binding]]
[[Category: Trevor C]]
[[Category: Trypanosoma brucei trypanosome transferrin receptor transferrrin cell surface]]

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