6tas: Difference between revisions

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-'''Unreleased structure'''
-The entry 6tas is ON HOLD
+==Structure of the two-fold capsomer of the dArc1 capsid==
+<StructureSection load='6tas' size='340' side='right'caption='[[6tas]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6tas]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TAS FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tas OCA], [http://pdbe.org/6tas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tas RCSB], [http://www.ebi.ac.uk/pdbsum/6tas PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tas ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ARC1_DROME ARC1_DROME]] Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles (PubMed:29328915). Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation (PubMed:29328915). Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction (PubMed:29328915). May play a role in energy balance: required for regulation of body fat by a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage (PubMed:26209258).<ref>PMID:26209258</ref> <ref>PMID:29328915</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Briggs, J A.G]]
+[[Category: Erlendsson, S]]
+[[Category: Morado, D R]]
+[[Category: Shepherd, J D]]
+[[Category: Darc]]
+[[Category: Gag]]
+[[Category: Virus]]
+[[Category: Virus like particle]]
+[[Category: Vlp]]