6uni: Difference between revisions

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-'''Unreleased structure'''
-The entry 6uni is ON HOLD  until Paper Publication
+==Human CYP3A4 bound to an inhibitor==
+<StructureSection load='6uni' size='340' side='right'caption='[[6uni]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-Authors: Sevrioukova, I.F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6uni]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UNI FirstGlance]. <br>
-Description: Human CYP3A4 bound to an inhibitor
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=QDV:tert-butyl+[(2S)-1-(1H-indol-3-yl)-3-{[(2R)-1-oxo-3-phenyl-1-{[2-(pyridin-3-yl)ethyl]amino}propan-2-yl]sulfanyl}propan-2-yl]carbamate'>QDV</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6une|6une]], [[6ung|6ung]], [[6unh|6unh]]</td></tr>
-[[Category: Sevrioukova, I.F]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uni OCA], [http://pdbe.org/6uni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uni RCSB], [http://www.ebi.ac.uk/pdbsum/6uni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uni ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Sevrioukova, I F]]
+[[Category: Complex]]
+[[Category: Cyp3a4]]
+[[Category: Inhibitor]]
+[[Category: Oxidoreductase]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]