Major histocompatibility complex: Difference between revisions
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== Function == | == Function == | ||
''' Major Histocompatibility Complex''' (MHC) are part of the | ''' Major Histocompatibility Complex''' (MHC) are part of the adaptive immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | ||
* '''MHC class I''' ([[Major Histocompatibility Complex Class I]]) are found in all nucleated cells. These cell surface proteins display peptides from cellular intrinsic proteins<ref>PMID:18675588</ref>. For more details see <br /> | * '''MHC class I''' ([[Major Histocompatibility Complex Class I]]) are found in all nucleated cells. These cell surface proteins display peptides from cellular intrinsic proteins<ref>PMID:18675588</ref>. For more details see <br /> | ||
*[[Effect of HCMV on Major Histocompatibility Complex Class I]]<br /> | *[[Effect of HCMV on Major Histocompatibility Complex Class I]]<br /> |
Revision as of 22:10, 21 July 2020
Function Major Histocompatibility Complex (MHC) are part of the adaptive immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.
For MHC class II interactions with T-cell receptor and gliadin peptide see SP3.4-TCR-HLA-DQ8-α-1-gliadin complex. Structural highlights. The [3]. Water molecules shown as red spheres. 3D structures of MHC |
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ReferencesReferences
- ↑ Raghavan M, Del Cid N, Rizvi SM, Peters LR. MHC class I assembly: out and about. Trends Immunol. 2008 Sep;29(9):436-43. doi: 10.1016/j.it.2008.06.004. PMID:18675588 doi:http://dx.doi.org/10.1016/j.it.2008.06.004
- ↑ Holling TM, Schooten E, van Den Elsen PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum Immunol. 2004 Apr;65(4):282-90. PMID:15120183 doi:http://dx.doi.org/10.1016/j.humimm.2004.01.005
- ↑ Liu J, Chen KY, Ren EC. Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: Towards designing better vaccines. Eur J Immunol. 2011 Jul;41(7):2097-106. doi: 10.1002/eji.201041370. PMID:21538979 doi:10.1002/eji.201041370