Major histocompatibility complex: Difference between revisions

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<StructureSection load='' size='350' side='right' caption='Human MHC class I antigen (cyan) with β 2-microglobulin (green) and peptide from Hepatitis virus (deeppink) [[3ox8]]' scene='45/457390/Cv/1'>
<StructureSection load='' size='350' side='right' caption='Human MHC class I antigen (cyan) with β 2-microglobulin (green) and peptide from Hepatitis virus (deeppink) [[3ox8]]' scene='45/457390/Cv/1'>
__TOC__
== Function ==
== Function ==
''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system.  MHC molecules display antigens on the host cell’s surface.  T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br />
''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system.  MHC molecules display antigens on the host cell’s surface.  T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br />
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[[MHC 3D structures of MHC]]
[[MHC 3D structures of MHC]]
</StructureSection>
</StructureSection>
==3D structures of MHC==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*'''MHC I'''
*MHC I binary complex
**[[2hla]], [[3hla]], [[1hla]] - hMHC  I + β-2-microglobulin – human<br />
**[[1zs8]] - mMHC  I + β-2-microglobulin – mouse<br />
**[[3p73]], [[3p77]] - cMHC  I + β-2-microglobulin – chicken
*MHC I ternary complex
**[[4d0b]], [[3bew]], [[2yez]], [[5ad0]], [[4d0c]], [[3bev]], [[4cvx]] – cMHC I α + β-2-microglobulin + peptide<br />
**[[3kpn]], [[3kpo]] – hMHC I B + β-2-microglobulin + peptide<br />
**[[3bev]], [[1kpr]], [[1k5n]], [[3nfn]], [[3mr9]], [[3mrb]], [[3mrc]], [[3mrd]], [[3mre]], [[3mrf]], [[3mrg]], [[3mrh]], [[3mri]], [[3mrj]], [[3mrk]], [[3mrl]], [[3mrm]], [[3mrn]], [[3mro]], [[3mrp]], [[3mrq]], [[3mrr]], [[3ox8]], [[3oxr]], [[3oxs]], [[2xpg]], [[3pwj]], [[3pwl]], [[3pwn]], [[3pwp]], [[2x70]], [[3o3a]], [[3o3b]], [[3o3d]], [[3o3e]], [[3lv3]], [[3ln4]], [[3ln5]], [[3myj]], [[3i6l]], [[3lkn]], [[3lko]], [[3lkp]], [[3lkq]], [[3lkr]], [[3lks]], [[3hpj]], [[3i6g]], [[3i6k]], [[3mgo]], [[3mgt]], [[3l3d]], [[3l3g]], [[3l3i]], [[3l3j]], [[3l3k]], [[2x4n]], [[2x4o]], [[2x4p]], [[2x4q]], [[2x4r]], [[2x4s]], [[2x4t]], [[2x4u]], [[3lka]], [[3h7b]], [[3kpl]], [[3kpm]], [[3kpn]], [[3kpo]], [[3kpp]], [[3kpq]], [[3kpr]], [[3kps]], [[3giv]], [[3hcv]], [[3d18]], [[3dtx]], [[3czf]], [[3fqn]], [[3fqr]], [[3fqt]], [[3fqu]], [[3fqw]], [[3fqx]], [[3d25]], [[3bvn]], [[3dx6]], [[3dx7]], [[3dx8]], [[3dxa]], [[3bo8]], [[3bp4]], [[3bp7]], [[3bgm]], [[3bh8]], [[3bh9]], [[3bhb]], [[3b3i]], [[3b6s]], [[2rfx]], [[3bze]], [[3bzf]], [[3bw9]], [[3bwa]], [[3c9n]], [[2v2w]], [[2v2x]], [[2gt9]], [[2gtw]], [[2gtz]], [[2guo]], [[2nw3]], [[2fyy]], [[2fz3]], [[2hn7]], [[2cik]], [[2git]], [[2hjk]], [[2hjl]], [[2h6p]], [[2d31]], [[2c7u]], [[2bck]], [[2a83]], [[2axf]], [[2axg]], [[2bvo]], [[2bvp]], [[2bvq]], [[1s8d]], [[1t1w]], [[1t1x]], [[1t1y]], [[1t1z]], [[1t20]], [[1t21]], [[1t22]], [[1s7q]], [[1zsd]], [[2bsr]], [[2bss]], [[2bst]], [[1zhk]], [[1zhl]], [[1tvb]], [[1tvh]], [[1xr8]], [[1xr9]], [[1w0v]], [[1w0w]], [[1xh3]], [[1uxs]], [[1uxw]], [[1s9w]], [[1s9x]], [[1s9y]], [[1q94]], [[1qvo]], [[1n2r]], [[1ogt]], [[1qew]], [[1jge]], [[1k5n]], [[1i7r]], [[1i7t]], [[1i7u]], [[1jf1]], [[1jht]], [[1i4f]], [[1e27]], [[1e28]], [[1i1y]], [[1i1f]], [[1qqd]], [[1mhe]], [[1b0g]], [[1a9b]], [[1a9e]], [[1a1m]], [[1a1n]], [[1a1o]], [[1tmc]], [[2clr]], [[1hhg]], [[1hhh]], [[1hhi]], [[1hhj]], [[1hhk]], [[1hsb]], [[1hsa]], [[3to2]], [[2vab]] - hMHC I α + β-2-microglobulin + peptide<br />
**[[1ktl]], [[3kww]], [[3h9h]], [[3ixa]], [[3gso]], [[3gsq]], [[3gsr]], [[3gsu]], [[3gsv]], [[3gsw]], [[3gsx]], [[3ft2]], [[3ft3]], [[3ft4]], [[2av1]], [[2av7]], [[1cg9]], [[1m05]], [[1m6o]], [[1kpr]], [[1ktl]] - hMHC I α (mutant) + β-2-microglobulin + peptide<br />
**[[1syv]], [[1n2r]], [[1syv]] - hMHC I  + β-2-microglobulin + hMHC II peptide<br />
**[[1kjv]], [[1kjm]], [[1ed3]] – MHC I α + β-2-microglobulin + peptide - rat<br />
**[[2oi9]] - mMHC  I α + T cell receptor + peptide<br />
**[[1kbg]], [[3l3h]], [[3ftg]], [[3e6f]], [[3ecb]], [[3ch1]], [[3cch]], [[3cc5]], [[3cpl]], [[2zsv]], [[2zsw]], [[2zok]], [[2zol]], [[3buy]], [[2ve6]], [[2e7l]], [[2fo4]], [[2cii]], [[2fwo]], [[2f74]], [[1zt1]], [[1zt7]], [[1vgk]], [[1yn6]], [[1yn7]], [[1zhb]], [[1wbx]], [[1wby]], [[1wbz]], [[1rjy]], [[1rjz]], [[1rk0]], [[1rk1]], [[1t0m]], [[1t0n]], [[1s7q]], [[1s7r]], [[1s7s]], [[1s7t]], [[1s7u]], [[1s7v]], [[1s7w]], [[1s7x]], [[1lk2]], [[1kpu]], [[1kpv]], [[1n3n]], [[1nan]], [[1n59]], [[1n5a]], [[1ffn]], [[1ffo]], [[1ffp]], [[1g7p]], [[1g7q]], [[1lek]], [[1leg]], [[1inq]], [[1juf]], [[1k8d]], [[1jpf]], [[1jpg]], [[1fg2]], [[1qlf]], [[1bz9]], [[1kbg]], [[1hoc]], [[2mha]], [[1vad]], [[1vac]], [[3roo]], [[3quk]], [[3qul]], [[3rol]], [[3tbs]], [[3tbt]], [[3tbv]], [[3tbw]], [[4nsk]], [[3tby]] - mMHC  I + β-2-microglobulin + peptide<br />
**[[2qri]] - mMHC  I/β-2-microglobulin/peptide<br />
**[[2qrs]], [[2qrt]] - mMHC  I (mutant)/β-2-microglobulin/peptide<br />
**[[1mhc]], [[2clv]], [[2clz]], [[1fzj]], [[1fzk]], [[1fzm]], [[1fzo]], [[1ddh]] - mMHC  I (mutant) + β-2-microglobulin + peptide<br />
**[[3e2h]], [[3e3q]], [[2e7l]] - mMHC  I α (mutant) + T cell receptor + peptide<br />
**[[1nez]] - mMHC  I + β-2-microglobulin + CD8 α chain<br />
**[[3rwc]], [[3rwd]], [[3rwe]], [[3rwf]], [[3rwg]], [[3rwh]], [[3rwi]], [[3rwj]], [[4zfz]], [[6iwg]], [[6hwj]] - MHC  I + β-2-microglobulin + peptide – Rhesus macaque<br />
**[[3qq3]], [[3qq4]] - MHC  I + β-2-microglobulin + peptide - pig<br />
**[[4d0b]], [[3bew]], [[2yez]], [[5ad0]], [[4d0c]], [[3bev]], [[4cvx]], [[4cvx]], [[4cvz]], [[4d0d]], [[4cw1]] – cMHC I α + β-2-microglobulin + peptide<br />
*MHC I quaternary complex
**[[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3mv7]], [[3mv9]], [[3h9s]], [[3gsn]], [[3d39]], [[3d3v]], [[3ffc]], [[2vlj]], [[2vlk]], [[2vll]], [[2vlr]], [[2j8u]], [[2p5e]], [[2p5w]], [[2pye]], [[2gj6]], [[2f54]], [[2esv]], [[2bnq]], [[2bnr]], [[1lp9]], [[1oga]], [[1mi5]], [[1qrn]] - hMHC  I α + T cell receptor + β-2-microglobulin + peptide<br />
**[[3kxf]], [[3mv8]], [[2jcc]], [[2uwe]] - hMHC  I α (mutant) + T cell receptor + β-2-microglobulin + peptide<br />
**[[2f53]] - hMHC  I α + T cell receptor + β-2-microglobulin (mutant) + peptide<br />
**[[1p7q]], [[1im9]] - hMHC  I α + leukocyte immunoglobulin-like receptor + β-2-microglobulin + peptide<br />
**[[2dyp]] - hMHC  I α (mutant) + leukocyte immunoglobulin-like receptor + β-2-microglobulin + peptide<br />
**[[3qzw]], [[3dmm]], [[1bqh]], [[1akj]] - hMHC I α + β-2-microglobulin + CD8 α + peptide<br />
**[[1im3]] - hMHC I α + β-2-microglobulin + cytomegalovirus protein US2 + peptide<br />
**[[3cii]], [[3cdg]] - hMHC I α + β-2-microglobulin + CD94 ectodomain + NKG2A/NKG2B integral membrane protein + peptide<br />
**[[3hae]], [[3gjf]], [[3cvh]], [[1w72]] - hMHC I α + β-2-microglobulin + antibody + peptide<br />
**[[1g6r]], [[2ckb]], [[3pqy]], [[2z31]], [[1nam]], [[1mwa]], [[1g6r]], [[2ckb]] - mMHC  I + T cell receptor + β-2-microglobulin + peptide<br />
**[[2oi9]] - mMHC  I (mutant) + T cell receptor + β-2-microglobulin + peptide<br />
**[[1p1z]], [[1p4l]], [[1qo3]] - mMHC  I + β-2-microglobulin + natural killer cell receptor LY49C + peptide<br />
**[[3c8k]] - mMHC  I (mutant) + β-2-microglobulin + natural killer cell receptor LY49C + peptide<br />
*'''MHC II'''
**[[3lqz]], [[2bc4]], [[1hdm]] - hMHC II α+β <br />
**[[3pdo]], [[3pgc]], [[3pgd]], [[1a6a]] - hMHC II α+β+γ<br />
**[[3cup]], [[2p24]], [[1lnu]], [[1fng]] - mMHC II α+β<br />
**[[1fne]] - mMHC II α+β (mutant) <br />
**[[3lqz]] - hMHC II α+β DP2
*MHC II binary complex
**[[1h15]] - hMHC II α+β + DNA polymerase peptide<br />
**[[1fv1]] - hMHC II α+β + myelin basic protein<br />
**[[3o6f]], [[2wbj]] - hMHC II α+β + T cell receptor<br />
**[[3l6f]], [[3c5j]], [[2q6w]], [[2fse]], [[1t5w]], [[1s9v]], [[1uvq]], [[1h15]], [[1fv1]] – hMHC II α+β + peptide<br />
**[[1dlh]] - hMHC II α+β + enterotoxin<br />
**[[3c5z]], [[3c60]], [[3c6l]] - mMHC II α+β + T cell receptor<br />
**[[1r5v]], [[1k2d]], [[1muj]], [[1kt2]], [[1ktd]], [[1f3j]], [[1es0]], [[1iak]], [[1iea]], [[1ieb]], [[1f3j]] - mMHC II α+β + peptide<br />
**[[1aqd]] - mMHC II α+β + MHC I peptide<br />
**[[1r5w]], [[1i3r]] - mMHC II α+β (mutant) + peptide<br />
*MHC II ternary complex
**[[1zgl]], [[1j8h]], [[1fyt]] - hMHC II α+β + T cell receptor + peptide<br />
**[[2iam]], [[2ian]], [[1ymm]], [[4gg6]] – hMHC II α+β + T cell receptor (mutant) + peptide<br />
**[[2ipk]], [[2g9h]], [[1pyw]], [[1jwm]], [[1jws]], [[1jwu]], [[1klg]], [[1klu]], [[1hxy]], [[1d5m]], [[1d5x]], [[1d5z]], [[1d6e]], [[2seb]], [[1seb]] - hMHC II α+β + enterotoxin + peptide<br />
**[[1sje]], [[1sjh]], [[1t5x]], [[1lo5]] - hMHC II α+β + enterotoxin (mutant) + peptide<br />
**[[1r5i]] - hMHC  II α+β + mycoplasma arthritidis mitogen+ peptide<br />
**[[2oje]] - mMHC  II α+β + mycoplasma arthritidis mitogen+ peptide<br />
**[[2xn9]], [[3qib]], [[1zgl]], [[3qiu]], [[3qiw]], [[3mbe]] - mMHC  I + T cell receptor + peptide<br />
**[[2pxy]], [[1u3h]] - mMHC II α+β + T cell receptor (mutant) + peptide<br />
**[[1jl4]] - mMHC II α+β + CD4 + peptide<br />
*MHC II quaternary complex
**[[2icw]] - mMHC  II α+β + T cell receptor + mycoplasma arthritidis mitogen + hemagglutinin peptide<br />
**[[4c56]] - hMHC  II + + T cell receptor + enterotoxin + hemagglutinin peptide<br />
}}


== References ==
== References ==

Revision as of 10:33, 28 October 2019

Function

Major Histocompatibility Complex (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.

For MHC class II interactions with T-cell receptor and gliadin peptide see SP3.4-TCR-HLA-DQ8-α-1-gliadin complex.

Structural highlights

.

The [3]. Water molecules shown as red spheres.

3D structures of MHC

MHC 3D structures of MHC

Human MHC class I antigen (cyan) with β 2-microglobulin (green) and peptide from Hepatitis virus (deeppink) 3ox8

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Raghavan M, Del Cid N, Rizvi SM, Peters LR. MHC class I assembly: out and about. Trends Immunol. 2008 Sep;29(9):436-43. doi: 10.1016/j.it.2008.06.004. PMID:18675588 doi:http://dx.doi.org/10.1016/j.it.2008.06.004
  2. ↑ Holling TM, Schooten E, van Den Elsen PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum Immunol. 2004 Apr;65(4):282-90. PMID:15120183 doi:http://dx.doi.org/10.1016/j.humimm.2004.01.005
  3. ↑ Liu J, Chen KY, Ren EC. Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: Towards designing better vaccines. Eur J Immunol. 2011 Jul;41(7):2097-106. doi: 10.1002/eji.201041370. PMID:21538979 doi:10.1002/eji.201041370

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Michal Harel, Joel L. Sussman, Alexander Berchansky, Tihitina Y Aytenfisu, Eric Martz, Sandra B. Gabelli
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