3bgp: Difference between revisions

Revision as of 20:32, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:3bgp.png

Template:STRUCTURE 3bgp

Human Pim-1 complexed with a benzoisoxazole inhibitor VX1Human Pim-1 complexed with a benzoisoxazole inhibitor VX1

Template:ABSTRACT PUBMED 18290603

About this StructureAbout this Structure

3BGP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase., Pierce AC, Jacobs M, Stuver-Moody C, J Med Chem. 2008 Mar 27;51(6):1972-5. Epub 2008 Feb 22. PMID:18290603

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Human Pim-1 complexed with a benzoisoxazole inhibitor VX1'''
+===Human Pim-1 complexed with a benzoisoxazole inhibitor VX1===
-==Overview==
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-To supplement the hits from a high throughput screen, docking was performed against Pim-1 kinase. Glide docking was augmented with a filter to require traditional or aromatic CH..O hydrogen bonds to the kinase hinge. Four diverse actives, of 96 molecules assayed, had K(i) values between 0.091 and 4.5 microM. This gives a 14-fold enrichment over the earlier HTS run, and the two crystal structures solved confirmed the binding modes predicted by docking.
+The line below this paragraph, {{ABSTRACT_PUBMED_18290603}}, adds the Publication Abstract to the page
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 ==About this Structure==
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 [[Category: Serine/threonine-protein kinase]]
 [[Category: Transferase]]
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