RNA Polymerase II: Difference between revisions
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== Introduction == | == Introduction == | ||
RNA polymerase II (RNAP II) is an enzyme that transcribes protein-encoding genes, therefore | RNA polymerase II (RNAP II) is an enzyme that transcribes protein-encoding genes, and it therefore is responsible for the synthesis of mRNA.Brief description of mRNA | ||
== Structural Components == | == Structural Components == | ||
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[[ Image:RnapII struct features.jpg|300px|left|thumb| The clamp (magenta), wall (navy blue), rudder (red), bridge (orange), RNA (light blue), and DNA (blue) are depicted. See below for PDB's and residue numbers.]] | [[ Image:RnapII struct features.jpg|300px|left|thumb| The clamp (magenta), wall (navy blue), rudder (red), bridge (orange), RNA (light blue), and DNA (blue) are depicted. See below for PDB's and residue numbers.]] | ||
To begin, the <scene name='82/824648/Clamp/ | To begin, the <scene name='82/824648/Clamp/3'>clamp</scene> swings to trap the DNA in the cleft. Further along, the <scene name='82/824648/Wall/1'>wall</scene> sends the DNA template through the cleft in approximately a 90° turn. Both the clamp and wall are parts of the Rpb2 subunit. Further along in the process, the <scene name='82/824648/Rudder/1'>rudder</scene> separates the newly synthesized RNA strand from the DNA template. The DNA reforms into a double helix as it leaves RNA pol II. | ||
Other components of RNA pol II include the following: | Other components of RNA pol II include the following: | ||