6su2: Difference between revisions

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-'''Unreleased structure'''
-The entry 6su2 is ON HOLD
+==Trypanosoma congolense pyruvate kinase in complex with citrate and glycerol==
+<StructureSection load='6su2' size='340' side='right'caption='[[6su2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6su2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SU2 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6su2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6su2 OCA], [http://pdbe.org/6su2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6su2 RCSB], [http://www.ebi.ac.uk/pdbsum/6su2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6su2 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Trypanosoma are blood-borne parasites and are the causative agents of neglected tropical diseases (NTDs) affecting both humans and animals. These parasites mainly rely on glycolysis for their energy production within the mammalian host, which is why trypanosomal glycolytic enzymes have been pursued as interesting targets for the development of trypanocidal drugs. The structure-function relationships of pyruvate kinases (PYKs) from trypanosomatids (Trypanosoma and Leishmania) have been well-studied within this context. In this paper, we describe the structural and enzymatic characterization of PYK from T. congolense (TcoPYK), the main causative agent of Animal African Trypanosomosis (AAT), by employing a combination of enzymatic assays, thermal unfolding studies and X-ray crystallography.
-Authors: Sterckx, Y.G.-J., Pinto Torres, J.E.
+Structural and kinetic characterization of Trypanosoma congolense pyruvate kinase.,Pinto Torres JE, Yuan M, Goossens J, Versees W, Caljon G, Michels PA, Walkinshaw MD, Magez S, Sterckx YG Mol Biochem Parasitol. 2020 Feb 19;236:111263. doi:, 10.1016/j.molbiopara.2020.111263. PMID:32084384<ref>PMID:32084384</ref>
-Description: Trypanosoma congolense pyruvate kinase in complex with citrate and glycerol
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Sterckx, Y.G.-J]]
+<div class="pdbe-citations 6su2" style="background-color:#fffaf0;"></div>
-[[Category: Pinto Torres, J.E]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Pyruvate kinase]]
+[[Category: Sterckx, Y G.J]]
+[[Category: Torres, J E.Pinto]]
+[[Category: Complex]]
+[[Category: Glycolysis]]
+[[Category: Transferase]]
+[[Category: Trypanosome]]