Severin: Difference between revisions

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== 3D Structures of Severin ==
== 3D Structures of Severin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[3fg6]] – Adseverin C-terminal – human<br />
[[3fg6]] – Adseverin C-terminal – human<br />
[[1svy]] – DdSeverin domain 2 – ''Dictyostelium discoideum'' <br />
[[1svy]] – DdSeverin domain 2 – ''Dictyostelium discoideum'' <br />

Latest revision as of 13:26, 19 November 2023


Severin is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins[1]. It is named Adseverin and Scinderin as well.

  • . Water molecules are shown as red spheres.
  • .


Severin domain 2 complex with Ca+2 (green) and Na+ (purple) ions 1svy

Drag the structure with the mouse to rotate

3D Structures of Severin3D Structures of Severin

Updated on 19-November-2023

3fg6 – Adseverin C-terminal – human
1svy – DdSeverin domain 2 – Dictyostelium discoideum
1svq, 1svr - DdSeverin domain 2 - NMR

ReferencesReferences

  1. Summerscales J, Dawson JF. Probing Dictyostelium severin structure and function by cross linking to actin. Biochem Cell Biol. 2004 Apr;82(2):343-50. PMID:15060630 doi:http://dx.doi.org/10.1139/o04-002

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky