3c6r: Difference between revisions

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OCA

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-[[Image:3c6r.jpg|left|200px]]
+{{Seed}}
+[[Image:3c6r.png|left|200px]]
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 {{STRUCTURE_3c6r|  PDB=3c6r  |  SCENE=  }}
-'''Low pH Immature Dengue Virus'''
+===Low pH Immature Dengue Virus===
-==Overview==
+<!--
-Intracellular cleavage of immature flaviviruses is a critical step in assembly that generates the membrane fusion potential of the E glycoprotein. With cryo-electron microscopy we show that the immature dengue particles undergo a reversible conformational change at low pH that renders them accessible to furin cleavage. At a pH of 6.0, the E proteins are arranged in a herringbone pattern with the pr peptides docked onto the fusion loops, a configuration similar to that of the mature virion. After cleavage, the dissociation of pr is pH-dependent, suggesting that in the acidic environment of the trans-Golgi network pr is retained on the virion to prevent membrane fusion. These results suggest a mechanism by which flaviviruses are processed and stabilized in the host cell secretory pathway.
+The line below this paragraph, {{ABSTRACT_PUBMED_18369148}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18369148 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18369148}}
 ==About this Structure==
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 [[Category: Virion]]
 [[Category: Virus]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:52:27 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:11:24 2008''