6seg: Difference between revisions

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'''Unreleased structure'''


The entry 6seg is ON HOLD
==Class1: CENP-A nucleosome in complex with CENP-C central region==
 
<StructureSection load='6seg' size='340' side='right'caption='[[6seg]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6seg]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SEG FirstGlance]. <br>
Description:  
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6seg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6seg OCA], [http://pdbe.org/6seg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6seg RCSB], [http://www.ebi.ac.uk/pdbsum/6seg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6seg ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN]] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ali-Ahmad, A]]
[[Category: Bilokapic, S]]
[[Category: Halic, M]]
[[Category: Schafer, I B]]
[[Category: Sekulic, N]]
[[Category: Cenp-a]]
[[Category: Centromere]]
[[Category: Centromeric chromatin]]
[[Category: Nuclear protein]]
[[Category: Nucleosome]]

Revision as of 19:50, 14 August 2019

Class1: CENP-A nucleosome in complex with CENP-C central regionClass1: CENP-A nucleosome in complex with CENP-C central region

Structural highlights

6seg is a 10 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CENPA_HUMAN] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).[1] [2]

References

  1. ↑ Sekulic N, Bassett EA, Rogers DJ, Black BE. The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres. Nature. 2010 Aug 25. PMID:20739937 doi:10.1038/nature09323
  2. ↑ Hu H, Liu Y, Wang M, Fang J, Huang H, Yang N, Li Y, Wang J, Yao X, Shi Y, Li G, Xu RM. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. Genes Dev. 2011 May 1;25(9):901-6. Epub 2011 Apr 8. PMID:21478274 doi:10.1101/gad.2045111

6seg, resolution 3.10Å

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