Metabotropic glutamate receptor: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres. | <scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres. | ||
==3D structures of metabotropic glutamate receptor == | |||
[[Metabotropic glutamate receptor 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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*Metabotropic glutamate receptor 1 | *Metabotropic glutamate receptor 1 | ||
**[[3ks9]] – hMGluR1 (mutant) + antagonist - human<br /> | **[[3ks9]] – hMGluR1 (mutant) + antagonist - human<br /> | ||
**[[4or2]] - hMGluR1/cytochrome b526<br /> | **[[4or2]] - hMGluR1/cytochrome b526<br /> | ||
**[[1ewt]], [[1ewv]] - rMGluR1 LBD - rat<br /> | |||
**[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu<br /> | **[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu<br /> | ||
**[[1iss]] - rMGluR1 LBD + antagonist<br /> | **[[1iss]] - rMGluR1 LBD + antagonist<br /> | ||
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**[[5cnk]] – hMGluR3 LBD + Glu <br /> | **[[5cnk]] – hMGluR3 LBD + Glu <br /> | ||
**[[3sm9]] - hMGluR3 + antagonist<br /> | **[[3sm9]] - hMGluR3 + antagonist<br /> | ||
**[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br /> | **[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br /> | ||
**[[5cnm]] – hMGluR3 LBD + Glu analog<br /> | **[[5cnm]] – hMGluR3 LBD + Glu analog<br /> | ||
**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br /> | |||
**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br /> | |||
*Metabotropic glutamate receptor 5 | *Metabotropic glutamate receptor 5 | ||
**[[6n52]] – hMGluR5 – Cryo EM<br /> | |||
**[[6n51]], [[6n50]], [[6n4y]] – hMGluR5 + nanobody – Cryo EM<br /> | |||
**[[6n4x]] – hMGluR5 LBD<br /> | |||
**[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br /> | **[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br /> | ||
**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br /> | **[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br /> | ||
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**[[6bsz]] – hMGluR8 LBD + Glu <br /> | **[[6bsz]] – hMGluR8 LBD + Glu <br /> | ||
**[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br /> | **[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br /> | ||
**[[6e5v]] – hMGluR8 N-terminal (mutant) + inhibitor <br /> | |||
}} | }} | ||
==See Also== | ==See Also== | ||