6rv4: Difference between revisions

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-'''Unreleased structure'''
-The entry 6rv4 is ON HOLD  until Paper Publication
+==Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237==
+<StructureSection load='6rv4' size='340' side='right'caption='[[6rv4]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6rv4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RV4 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=KKZ:[4-[[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-[6-(trifluoromethyloxy)pyridin-2-yl]methanone'>KKZ</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rv4 OCA], [http://pdbe.org/6rv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rv4 RCSB], [http://www.ebi.ac.uk/pdbsum/6rv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rv4 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/KCNK3_HUMAN KCNK3_HUMAN]] Heritable pulmonary arterial hypertension. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/KCNK3_HUMAN KCNK3_HUMAN]] pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.<ref>PMID:23169818</ref> <ref>PMID:9312005</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Burgess-Brown, N]]
+[[Category: Bushell, S R]]
+[[Category: Carpenter, E P]]
+[[Category: Chalk, R]]
+[[Category: Edwards, A M]]
+[[Category: Mukhopadhyay, S M.M]]
+[[Category: Pike, A C.W]]
+[[Category: Quigley, A]]
+[[Category: Rodstrom, K E.J]]
+[[Category: Structural genomic]]
+[[Category: Shrestha, L]]
+[[Category: Speedman, D]]
+[[Category: Tessitore, A]]
+[[Category: Venkaya, S]]
+[[Category: Zhang, W]]
+[[Category: Membrane protein]]
+[[Category: Potassium channel]]
+[[Category: Sgc]]