6rv3: Difference between revisions

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-'''Unreleased structure'''
-The entry 6rv3 is ON HOLD  until Paper Publication
+==Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493==
+<StructureSection load='6rv3' size='340' side='right'caption='[[6rv3]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6rv3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RV3 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=KKQ:[4-[[2-(4-bromophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]piperazin-1-yl]-(2-fluorophenyl)methanone'>KKQ</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rv3 OCA], [http://pdbe.org/6rv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/6rv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rv3 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/KCNK3_HUMAN KCNK3_HUMAN]] Heritable pulmonary arterial hypertension. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/KCNK3_HUMAN KCNK3_HUMAN]] pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.<ref>PMID:23169818</ref> <ref>PMID:9312005</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Burgess-Brown, N]]
+[[Category: Bushell, S R]]
+[[Category: Carpenter, E P]]
+[[Category: Chalk, R]]
+[[Category: Edwards, A M]]
+[[Category: Mukhopadhyay, S M.M]]
+[[Category: Pike, A C.W]]
+[[Category: Quigley, A]]
+[[Category: Rodstrom, K E.J]]
+[[Category: Structural genomic]]
+[[Category: Shrestha, L]]
+[[Category: Speedman, D]]
+[[Category: Tessitore, A]]
+[[Category: Venkaya, S]]
+[[Category: Zhang, W]]
+[[Category: Membrane protein]]
+[[Category: Potassium channel]]
+[[Category: Sgc]]