5qrb: Difference between revisions

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'''Unreleased structure'''


The entry 5qrb is ON HOLD
==PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z2856434868==
 
<StructureSection load='5qrb' size='340' side='right'caption='[[5qrb]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
Authors: Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5qrb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QRB FirstGlance]. <br>
Description: PanDDA analysis group deposition --Crystal Structure of human ALAS2A in complex with Z2856434868
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NVY:1-ethyl-N-(2-fluorophenyl)piperidin-4-amine'>NVY</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
[[Category: Foster, W]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qrb OCA], [http://pdbe.org/5qrb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qrb RCSB], [http://www.ebi.ac.uk/pdbsum/5qrb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qrb ProSAT]</span></td></tr>
[[Category: Arrowsmith, C.H]]
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: 5-aminolevulinate synthase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Bailey, H]]
[[Category: Bezerra, G A]]
[[Category: Bountra, C]]
[[Category: Brandao-Neto, J]]
[[Category: Brandao-Neto, J]]
[[Category: Talon, R]]
[[Category: Brennan, P E]]
[[Category: Brennan, P.E]]
[[Category: Delft, F von]]
[[Category: Shrestha, L]]
[[Category: Douangamath, A]]
[[Category: Bezerra, G.A]]
[[Category: Edwards, A]]
[[Category: Edwards, A]]
[[Category: Nicola, B.B]]
[[Category: Foster, W]]
[[Category: Douangamath, A]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
[[Category: Yue, W.W]]
[[Category: Nicola, B B]]
[[Category: Von Delft, F]]
[[Category: Shrestha, L]]
[[Category: Bailey, H]]
[[Category: Talon, R]]
[[Category: Bountra, C]]
[[Category: Yue, W W]]
[[Category: Pandda]]
[[Category: Sgc - diamond i04-1 fragment screening]]
[[Category: Transferase]]
[[Category: Xchemexplorer]]

Revision as of 08:45, 7 August 2019

PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z2856434868PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z2856434868

Structural highlights

5qrb is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:5-aminolevulinate synthase, with EC number 2.3.1.37
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[HEM0_HUMAN] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).[1]

References

  1. ↑ Ducamp S, Kannengiesser C, Touati M, Garcon L, Guerci-Bresler A, Guichard JF, Vermylen C, Dochir J, Poirel HA, Fouyssac F, Mansuy L, Leroux G, Tertian G, Girot R, Heimpel H, Matthes T, Talbi N, Deybach JC, Beaumont C, Puy H, Grandchamp B. Sideroblastic anemia: molecular analysis of the ALAS2 gene in a series of 29 probands and functional studies of 10 missense mutations. Hum Mutat. 2011 Jun;32(6):590-7. doi: 10.1002/humu.21455. Epub 2011 Feb 24. PMID:21309041 doi:http://dx.doi.org/10.1002/humu.21455

5qrb, resolution 1.72Å

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OCA
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