Flagellin: Difference between revisions

Latest revision as of 09:37, 3 July 2019

Function

Flagellin (Fla) from Salmonella typhimurium is the major molecular trigger by which the pathogen activates gut epithelial proinflammatory gene expression^[1]. Toll-like receptor 5 (TLR5) recognizes bacterial Fla and this association mediates the innate immune response to the bacteria^[2].

Structural highlights

^[3].

3D Structures of flagellin

Flagellin 3D structures

Glycosylated flagellin (pink, yellow) complex with TLR5 (grey, green) (PDB code 3v47)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Zeng H, Carlson AQ, Guo Y, Yu Y, Collier-Hyams LS, Madara JL, Gewirtz AT, Neish AS. Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol. 2003 Oct 1;171(7):3668-74. PMID:14500664
↑ Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103. PMID:11323673 doi:http://dx.doi.org/10.1038/35074106
↑ Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA. Structural basis of TLR5-flagellin recognition and signaling. Science. 2012 Feb 17;335(6070):859-64. PMID:22344444 doi:10.1126/science.1215584

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Michal Harel, Joel L. Sussman, Alexander Berchansky

[1] Zeng H, Carlson AQ, Guo Y, Yu Y, Collier-Hyams LS, Madara JL, Gewirtz AT, Neish AS. Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol. 2003 Oct 1;171(7):3668-74. PMID:14500664

[2] Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103. PMID:11323673 doi:http://dx.doi.org/10.1038/35074106

[3] Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA. Structural basis of TLR5-flagellin recognition and signaling. Science. 2012 Feb 17;335(6070):859-64. PMID:22344444 doi:10.1126/science.1215584

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 </StructureSection>
-== 3D Structures of flagellin ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-* Flagellin
-**[[5o4u]] – Fla – ''Pyrococcus furiosus'' – Cryo EM <br />
-**[[1ucu]], [[3a5x]] – StFla phase1 – ''Salmonella typhimurium'' – Cryo EM<br />
-**[[1io1]] – StFla phase1 residues 54-451 (mutant) <br />
-**[[5wk5]], [[5wk6]] – Fla FliC – ''Pseudomonas aeruginosa'' – Cryo EM<br />
-**[[4nx9]] – Fla FliC residues 56-342 (mutant)  <br />
-**[[4cfi]] – Fla FliC residues 69-326 – ''Burkholderia pseudomallei'' <br />
-**[[4iwb]] – AaFla FliC/FliS – ''Aquifex aeolicus'' <br />
-**[[5tfy]] – Fla – ''Methanospirillum hungatei'' – Cryo EM <br />
-**[[5wjt]], [[5wju]], [[5wjv]], [[5wjw]], [[5wjx]], [[5wjy]], [[5wjz]] – BsFla – ''Bacillus subtilis'' – Cryo EM<br />
-**[[2zbi]] – Fla - ''Sphingomonas''<br />
-**[[5z7q]] – Fla residues 54-229 – ''Bacillus cereus'' <br />
-**[[5z1l]] – Fla – ''Methanococcus maripaludis'' – Cryo EM<br />
-* Flagellin complex
-**[[5gna]] – StFla FliT residues 1-94 + flagellar hook-associated protein 2 <br />
-**[[6b5b]] – Fla + NAIP5 + NLRC4 – ''Legionella pneumophila'' – Cryo EM <br />
-**[[3v47]] – Fla phase1 + TLR5 – ''Salmonella enterica''<br />
-**[[5gy2]] – BsFla residues 54-230 + TLR5 <br />
-**[[6gow]], [[5maw]] – BsFla + FliS <br />
-**[[1ory]] – AaFla FliC residues 464-518 + FliS  <br />
-**[[5yud]] – StFla + Naip5 <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]