Dihydrofolate reductase 3D structures: Difference between revisions
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**[[1j3k]], [[1j3j]], [[3jsu]], [[6a2l]], [[6a2n]], [[6a2p]] - PfDHFR-TS (mutant)+NADPH+dUMP+ inhibitor<br /> | **[[1j3k]], [[1j3j]], [[3jsu]], [[6a2l]], [[6a2n]], [[6a2p]] - PfDHFR-TS (mutant)+NADPH+dUMP+ inhibitor<br /> | ||
**[[3qg2]] - PfDHFR-TS (mutant)+NADPH + inhibitor<br /> | **[[3qg2]] - PfDHFR-TS (mutant)+NADPH + inhibitor<br /> | ||
**[[ | **[[3um8]], [[4dph]], [[6kot]] - PfDHFR-TS + NADPH + anti-malarial drug<br /> | ||
**[[ | **[[3um5]], [[3um6]], [[4dp3]], [[6kp2]], [[6kp7]], [[6kpr]] - PfDHFR-TS (mutant)+NADPH + dUMP + anti-malarial drug<br /> | ||
**[[4dpd]] - PfDHFR-TS +NADPH + dUMP + folate<br /> | **[[4dpd]] - PfDHFR-TS +NADPH + dUMP + folate<br /> | ||
**[[3k2h]], [[3nrr]] - BbDHFR-TS+NADPH+dUMP+inhibitor<br /> | **[[3k2h]], [[3nrr]] - BbDHFR-TS+NADPH+dUMP+inhibitor<br /> | ||
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**[[5t0l]], [[6n1t]] - TgDHFR-TS + NADPH + dUMP + folate derivative + inhibitor<br /> | **[[5t0l]], [[6n1t]] - TgDHFR-TS + NADPH + dUMP + folate derivative + inhibitor<br /> | ||
**[[3hj3]] - ChDHFR-TS + NADPH + dUMP + MTX <br /> | **[[3hj3]] - ChDHFR-TS + NADPH + dUMP + MTX <br /> | ||
**[[4ky8]], [[4q0d]], [[4q0e]] - ChDHFR-TS + NADPH + dUMP + MTX + pyrimidine derivative <br /> | **[[4ky8]], [[4q0d]], [[4q0e]], [[6ojs]], [[6pf7]], [[6pf8]], [[6pf9]], [[6pfa]], [[6pfb]], [[6pfc]], [[6pfd]], [[6pfe]], [[6pff]], [[6pfg]], [[6pfh]], [[6pfi]] - ChDHFR-TS + NADPH + dUMP + MTX + pyrimidine derivative <br /> | ||
**[[6aog]], [[6aoh]], [[6aoi]] - TgDHFR-TS + NADPH + dUMP + folate derivative + inhibitor<br /> | **[[6aog]], [[6aoh]], [[6aoi]] - TgDHFR-TS + NADPH + dUMP + folate derivative + inhibitor<br /> | ||
**[[6n1s]] - TgDHFR-TS (mutant) + NADPH + dUMP + folate derivative + inhibitor<br /> | **[[6n1s]] - TgDHFR-TS (mutant) + NADPH + dUMP + folate derivative + inhibitor<br /> | ||
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**[[2cig]] – MtDHFR+isoniazid derivative – ''Mycobacterium tuberculosis''<br /> | **[[2cig]] – MtDHFR+isoniazid derivative – ''Mycobacterium tuberculosis''<br /> | ||
**[[4klx]] - MtDHFR + ADP<br /> | **[[4klx]] - MtDHFR + ADP<br /> | ||
**[[3tq8]] - CbDHFR+TMP – ''Coxiella burnetii''<br /> | **[[3tq8]] - CbDHFR + TMP – ''Coxiella burnetii''<br /> | ||
**[[3tq9]] – CbDHFR + MTX<br /> | **[[3tq9]] – CbDHFR + MTX<br /> | ||
**[[4qi9]], [[5hi6]] - YpDHFR + MTX <br /> | **[[4qi9]], [[5hi6]] - YpDHFR + MTX <br /> | ||
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**[[4ddr]], [[4kak]], [[4kbn]], [[4kd7]], [[4keb]], [[4kfj]], [[4qhv]], [[4qjc]], [[5hpb]], [[5hqy]], [[5hqz]], [[5hsr]], [[5hsu]], [[5ht4]], [[5ht5]], [[5hui]], [[5hvb]], [[5hve]], [[1kms]], [[1kmv]], [[3ntz]], [[3nxx]], [[3nxy]], [[6a7c]], [[6a7e]], [[6de4]] – hDHFR + NADPH + pyrimidine inhibitor<br /> | **[[4ddr]], [[4kak]], [[4kbn]], [[4kd7]], [[4keb]], [[4kfj]], [[4qhv]], [[4qjc]], [[5hpb]], [[5hqy]], [[5hqz]], [[5hsr]], [[5hsu]], [[5ht4]], [[5ht5]], [[5hui]], [[5hvb]], [[5hve]], [[1kms]], [[1kmv]], [[3ntz]], [[3nxx]], [[3nxy]], [[6a7c]], [[6a7e]], [[6de4]] – hDHFR + NADPH + pyrimidine inhibitor<br /> | ||
**[[3sgy]], [[3sh2]], [[4tu5]], [[4xe6]], [[4xec]], [[5hf0]], [[5hf2]], [[5jg0]], [[6e4e]] - SaDHFR +NADP+ pyrimidine derivative<br /> | **[[3sgy]], [[3sh2]], [[4tu5]], [[4xe6]], [[4xec]], [[5hf0]], [[5hf2]], [[5jg0]], [[6e4e]], [[6nd2]], [[6pbo]] - SaDHFR +NADP+ pyrimidine derivative<br /> | ||
**[[3i8a]], [[3f0q]], [[3f0s]], [[3f0v]], [[3f0x]], [[3f0b]], [[3f0u]], [[3fq0]], [[3fqc]], [[3fqf]], [[3fqo]], [[3fqv]], [[3fqz]], [[3lg4]], [[5isp]], [[5isq]], [[5ist]] – SaDHFR (mutant)+NADPH+ pyrimidine derivative<br /> | **[[3i8a]], [[3f0q]], [[3f0s]], [[3f0v]], [[3f0x]], [[3f0b]], [[3f0u]], [[3fq0]], [[3fqc]], [[3fqf]], [[3fqo]], [[3fqv]], [[3fqz]], [[3lg4]], [[5isp]], [[5isq]], [[5ist]] – SaDHFR (mutant)+NADPH+ pyrimidine derivative<br /> | ||
**[[2w3w]] – MaDHFR+NADPH+ pyrimidine derivative<br /> | **[[2w3w]] – MaDHFR+NADPH+ pyrimidine derivative<br /> | ||
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**[[4h95]], [[4h96]], [[4h97]], [[4hoe]], [[4hof]] - CaDHFR + NADPH + pyrimidine derivative<br /> | **[[4h95]], [[4h96]], [[4h97]], [[4hoe]], [[4hof]] - CaDHFR + NADPH + pyrimidine derivative<br /> | ||
**[[4km0]] – MtDHFR + ADP + pyrimidine derivative<br /> | **[[4km0]] – MtDHFR + ADP + pyrimidine derivative<br /> | ||
**[[5ja3]], [[5u26]], [[5u27]], [[5ujf]], [[6ddp]], [[6dds]], [[6ddw]] – MtDHFR + NADP + pyrimidine derivative<br /> | **[[5ja3]], [[5u26]], [[5u27]], [[5ujf]], [[6ddp]], [[6dds]], [[6ddw]], [[6nnc]], [[6nne]] – MtDHFR + NADP + pyrimidine derivative<br /> | ||
**[[3nza]] - PncDHFR+NADPH+ pyrimidine derivative<br /> | **[[3nza]] - PncDHFR+NADPH+ pyrimidine derivative<br /> | ||
**[[4m7v]] - EfDHFR +NADPH + pyrimidine derivative - ''Enterococcus faecalis'' <br /> | **[[4m7v]] - EfDHFR +NADPH + pyrimidine derivative - ''Enterococcus faecalis'' <br /> | ||
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*''Ternary complexes with quinazoline derivative'' | *''Ternary complexes with quinazoline derivative'' | ||
**[[1boz]] – hDHFR (mutant)+NADPH+quinazoline derivative<br /> | |||
**[[4lae]], [[4lag]], [[4lah]], [[4lek]] - SaDHFR +NADPH+ quinazoline derivative<br /> | **[[4lae]], [[4lag]], [[4lah]], [[4lek]] - SaDHFR +NADPH+ quinazoline derivative<br /> | ||
**[[3qyl]], [[3qyo]], [[3r33]], [[3kfy]] - EcDHFR +NADPH+quinazoline derivative<br /> | **[[3qyl]], [[3qyo]], [[3r33]], [[3kfy]] - EcDHFR +NADPH+quinazoline derivative<br /> | ||
**[[1ly3]], [[1s3y]] – PcDHFR +NAP+quinazoline derivative<br /> | **[[1ly3]], [[1s3y]] – PcDHFR +NAP+quinazoline derivative<br /> | ||
**[[1m79]], [[1m78]], [[1m7a]], [[1ia1]], [[1ia2]], [[1ia3]], [[1ia4]], [[1aoe]] – CaDHFR+NADPH+quinazoline derivative <br /> | **[[1m79]], [[1m78]], [[1m7a]], [[1ia1]], [[1ia2]], [[1ia3]], [[1ia4]], [[1aoe]] – CaDHFR+NADPH+quinazoline derivative <br /> | ||
**[[1sej]] - ChDHFR +NADPH+quinazoline derivative+deoxyuridine <br /> | **[[1sej]] - ChDHFR +NADPH+quinazoline derivative+deoxyuridine <br /> | ||
**[[6dtc]] – DHFR +NADPH+quinazoline derivative – ''Aspergillus flavus''<br /> | |||
*''Ternary complexes with TMP'' | *''Ternary complexes with TMP'' | ||
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*''Ternary complexes with MTX'' | *''Ternary complexes with MTX'' | ||
**[[1u71]], [[1u72]] - hDHFR (mutant)+MTX+NADPH<BR /> | |||
**[[3ia4]] – MpDHFR+ MTX +NADPH<BR /> | **[[3ia4]] – MpDHFR+ MTX +NADPH<BR /> | ||
**[[3dat]] - | **[[3dat]] - BaDHFR+ MTX+NADPH<BR /> | ||
**[[1bzf]] - LcDHFR+NADPH+ TMX – NMR<BR /> | **[[1bzf]] - LcDHFR+NADPH+ TMX – NMR<BR /> | ||
**[[1u70]] – mDHFR (mutant)+MTX+NADPH<BR /> | **[[1u70]] – mDHFR (mutant)+MTX+NADPH<BR /> | ||
**[[1dre]], [[1rb3]], [[1rg7]], [[1rh3]], [[1ra3]], [[1rx3]], [[3dau]], [[4gh8]] - EcDHFR+NADP+MTX<br /> | **[[1dre]], [[1rb3]], [[1rg7]], [[1rh3]], [[1ra3]], [[1rx3]], [[3dau]], [[4gh8]] - EcDHFR+NADP+MTX<br /> | ||
**[[1ddr]] - EcDHFR+MTX+urea<br /> | **[[1ddr]] - EcDHFR+MTX+urea<br /> | ||
**[[1tdr]] - EcDHFR+MTX+Te<br /> | **[[1tdr]] - EcDHFR+MTX+Te<br /> | ||
**[[ | **[[6p9z]], [[6wep]] - SaDHFR +MTX+NADPH<BR /> | ||
**[[1df7]] - MtDHFR +MTX+NADPH<BR /> | **[[1df7]] - MtDHFR +MTX+NADPH<BR /> | ||
**[[3ix9]] – DHFR (mutant) +MTX+NADPH – ''Streptococcus pneumoniae''<br /> | **[[3ix9]] – DHFR (mutant) +MTX+NADPH – ''Streptococcus pneumoniae''<br /> | ||
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*''Other ternary complexes '' | *''Other ternary complexes '' | ||
**[[3k45]], [[3k47]] – mDHFR+E & Z-isomer+NADPH – mouse<br /> | |||
**[[3d80]], [[3d84]] – mDHFR+NADPH+ pteridin derivative<br /> | |||
**[[1klk]] – DHFR+NADPH+PT653 – rat<br /> | |||
**[[1dr1]], [[1dr2]], [[1dr3]] - cDHFR+NADP+biopterin – chicken<br /> | |||
**[[1dr4]], [[1dr5]], [[1dr6]], [[1dr7]] - cDHFR+NADP+biopterin+Hg<br /> | |||
**[[3m08]] - SaDHFR+RAB1+NADP<br /> | **[[3m08]] - SaDHFR+RAB1+NADP<br /> | ||
**[[3m09]] – SaDHFR (mutant)+RAB1+NADP<br > | **[[3m09]] – SaDHFR (mutant)+RAB1+NADP<br > | ||
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**[[3fyv]] – SaDHFR (mutant)+ AR-102+NADPH<BR /> | **[[3fyv]] – SaDHFR (mutant)+ AR-102+NADPH<BR /> | ||
**[[3fyw]] – SaDHFR + AR-101+NADPH<BR /> | **[[3fyw]] – SaDHFR + AR-101+NADPH<BR /> | ||
**[[3frf ]]– SaDHFR (mutant)+iclaprim+NADPH<BR | **[[3frf]] – SaDHFR (mutant)+iclaprim+NADPH<BR /> | ||
**[[2ano]], [[2anq]] - EcDHFR+NADPH+MS-SH08-17<br /> | **[[2ano]], [[2anq]] - EcDHFR+NADPH+MS-SH08-17<br /> | ||
**[[5uih]] - EcDHFR+NADP + drug<br /> | **[[5uih]] - EcDHFR+NADP + drug<br /> | ||
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**[[1vj3]] – PcHDFR+TAB+NADPH <br /> | **[[1vj3]] – PcHDFR+TAB+NADPH <br /> | ||
**[[4m2x]] - MtDHFR + trimetrexate +NADPH<br /> | **[[4m2x]] - MtDHFR + trimetrexate +NADPH<br /> | ||
**[[6nnd]] - MtDHFR + DHF +NADPH<br /> | |||
**[[6nnh]] - MtDHFR + cycloguanyl +NADPH<br /> | |||
**[[6nni]] - MtDHFR + pyrimethamine +NADPH<br /> | |||
**[[4kne]] - MtDHFR + ADP + anti-folate drug<br /> | **[[4kne]] - MtDHFR + ADP + anti-folate drug<br /> | ||
**[[1dg7]] - MtDHFR + 4-Br-WR99210 +NADPH<BR /> | **[[1dg7]] - MtDHFR + 4-Br-WR99210 +NADPH<BR /> | ||
*DHFR higher complexes | *DHFR higher complexes | ||
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**[[2xw7]] - DHFR +NADPH – ''Mycobacterium smegmatis''<br /> | **[[2xw7]] - DHFR +NADPH – ''Mycobacterium smegmatis''<br /> | ||
**[[4m7u]] - EfDHFR +NADPH <br /> | **[[4m7u]] - EfDHFR +NADPH <br /> | ||
**[[4q67]] - SaDHFR +NADPH <br /> | **[[4q67]], [[6pra]] - SaDHFR +NADPH <br /> | ||
**[[4q6a]] - SaDHFR (mutant) +NADPH <br /> | **[[4q6a]] - SaDHFR (mutant) +NADPH <br /> | ||