4wri: Difference between revisions
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<StructureSection load='4wri' size='340' side='right'caption='[[4wri]], [[Resolution|resolution]] 1.40Å' scene=''> | <StructureSection load='4wri' size='340' side='right'caption='[[4wri]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4wri]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4wri]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halichondria_okadai Halichondria okadai]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WRI FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=OKA:OKADAIC+ACID'>OKA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wri OCA], [https://pdbe.org/4wri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wri RCSB], [https://www.ebi.ac.uk/pdbsum/4wri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wri ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q2MHR1_HALOK Q2MHR1_HALOK] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Halichondria okadai]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ehara | [[Category: Ehara H]] | ||
[[Category: Fukuzawa | [[Category: Fukuzawa S]] | ||
[[Category: Ito | [[Category: Ito T]] | ||
[[Category: Kodama | [[Category: Kodama K]] | ||
[[Category: Makino | [[Category: Makino M]] | ||
[[Category: Sekine | [[Category: Sekine S]] | ||
[[Category: Tachibana | [[Category: Tachibana K]] | ||
[[Category: Yokoyama | [[Category: Yokoyama S]] | ||
Latest revision as of 10:22, 7 April 2023
Crystal structure of okadaic acid binding protein 2.1Crystal structure of okadaic acid binding protein 2.1
Structural highlights
FunctionPublication Abstract from PubMedOkadaic acid (OA) is a marine polyether cytotoxin that was first isolated from the marine sponge Halichondria okadai. OA is a potent inhibitor of protein serine/threonine phosphatases (PP) 1 and 2A, and the structural basis of phosphatase inhibition has been well investigated. However, the role and mechanism of OA retention in the marine sponge have remained elusive. We have solved the crystal structure of okadaic acid binding protein 2.1 (OABP2.1) isolated from H. okadai; it has strong affinity for OA and limited sequence homology to other proteins. The structure revealed that OABP2.1 consists of two alpha-helical domains, with the OA molecule deeply buried inside the protein. In addition, the global fold of OABP2.1 was unexpectedly similar to that of aequorin, a jellyfish photoprotein. The presence of structural homologues suggested that, by using similar protein scaffolds, marine invertebrates have developed diverse survival systems adapted to their living environments. Crystal Structure of Okadaic Acid Binding Protein 2.1: A Sponge Protein Implicated in Cytotoxin Accumulation.,Ehara H, Makino M, Kodama K, Konoki K, Ito T, Sekine SI, Fukuzawa S, Yokoyama S, Tachibana K Chembiochem. 2015 May 12. doi: 10.1002/cbic.201500141. PMID:25965326[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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