4uzk: Difference between revisions

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 <StructureSection load='4uzk' size='340' side='right'caption='[[4uzk]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4uzk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UZK FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4uzk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UZK FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uyu|4uyu]], [[4uyw|4uyw]], [[4uyz|4uyz]], [[4uz1|4uz1]], [[4uz5|4uz5]], [[4uz6|4uz6]], [[4uz7|4uz7]], [[4uz9|4uz9]], [[4uza|4uza]], [[4uzj|4uzj]], [[4uzl|4uzl]], [[4uzq|4uzq]], [[4wbh|4wbh]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzk OCA], [https://pdbe.org/4uzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uzk RCSB], [https://www.ebi.ac.uk/pdbsum/4uzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uzk ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzk OCA], [http://pdbe.org/4uzk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uzk RCSB], [http://www.ebi.ac.uk/pdbsum/4uzk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uzk ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/NOTUM_DROME NOTUM_DROME] Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175). Also acts as a regulator of long-range activity of Hedgehog (hh), possibly by regulating the switch between low and high level hh pathway signaling (PubMed:20412775, PubMed:22872085).[UniProtKB:Q6P988]<ref>PMID:20412775</ref> <ref>PMID:22872085</ref> <ref>PMID:25731175</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Carboxylesterase]]
+[[Category: Drosophila melanogaster]]
-[[Category: Drome]]
 [[Category: Large Structures]]
-[[Category: Jones, E Y]]
+[[Category: Jones EY]]
-[[Category: Zebisch, M]]
+[[Category: Zebisch M]]
-[[Category: Alpha/beta hydrolase]]
-[[Category: Esterase]]
-[[Category: Extracellular]]
-[[Category: Hydrolase]]